Guide to Fluorine NMR for Organic Chemists

"The flawless ordering of material covered in this stand–alone volume is such that information can be found very easily." Angewandte Chemie review of the first edition, 2010

Following its successful first edition, Guide to Fluorine NMR for Organic Chemists provides an unparalleled guide to fluorine NMR and the impact of fluorine substituents on proton and carbon NMR spectra. The author enhances each chapter with additional data and updated discussion of recent findings to continue helping working chemists overcome the challenges associated with the synthetic methodologies of fluorinated compounds.

After a thorough introduction of fluorinated compounds, chapters in the text cover:

An overview of fluorine NMR

The single fluorine substituent

The CF2 group

The trifluoromethyl group

More heavily fluorinated compounds

Compounds and substituents with fluorine directly bound to heteroatoms

Coverage ranges from those compounds containing only a few fluorinated substituents, typically employed in pharmaceutical and agricultural applications, to more heavily fluorinated compounds. Furthermore, the second edition features new discussion of nitrogen NMR and the influence of fluorine upon nitrogen NMR chemical shifts and coupling constants. Altogether, this information enables the effective use of these increasingly popular spectroscopic techniques to accurately characterize compounds that contain fluorine.

Featuring NMR data for more than 1,000 specific compounds and including more than 100 exemplary spectra, Guide to Fluorine NMR for Organic Chemists gives the working chemist and advanced student an essential tool for understanding cutting–edge NMR techniques and interpreting the resulting spectroscopic data.

William R. Dolbier, Jr., is the Col. Allen R. and Margaret G. Crow Professor of Chemistry at the University of Florida. He received his BS in chemistry from Stetson University in 1961 and his PhD in organic chemistry from Cornell University in 1965. Following a postdoctoral appointment at Yale University, he joined the faculty at the University of Florida in 1966. Professor Dolbier was the recipient of the 2000 American Chemical Society (ACS) Award for Creative Work in Fluorine Chemistry, and is a past member of the Executive Committee of the Fluorine Division of the ACS.