Cancer Cytogenetics: Chromosomal and Molecular Genetic Aberrations of Tumor Cells

Over the last four decades, cancer cytogenetics has become widely recognized both as a basic research tool for investigations of tumor biology and a clinical methodology providing vital insights into cancer development and progression. The first three editions of this acclaimed book presented a much–needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up–to–date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations.

Edited by two leading experts, and now involving an expanded panel of international experts, the book offers an authoritative description of neoplastic processes at the chromosomal level of genomic organization. Now in full color, Cancer Cytogenetics, Fourth Edition;

Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date, Offers greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations, Covers how molecular genetic data (PCR–based and sequencing information) are collated with the cytogenetic data where pertinent, Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible.
Cancer researchers, clinical oncologists, geneticists, and especially anyone interested in the translational aspects of bench–to–bedside research in cancer genetics will find this new edition indispensable as a reference and clinical tool.

Contributors vi

Preface to the Fourth Edition viii

1 How it all began: cancer cytogenetics before sequencing 1
Felix Mitelman and Sverre Heim

2 Cytogenetic methods 11
David Gisselsson

3 Cytogenetic nomenclature 19
Sverre Heim and Felix Mitelman

4 Nonrandom chromosome abnormalities in cancer: an overview 26
Sverre Heim and Felix Mitelman

5 From chromosomes to genes: searching for pathogenetic fusions in cancer 42
Ioannis Panagopoulos

6 Acute myeloid leukemia 62
Bertil Johansson and Christine J. Harrison

7 Myelodysplastic syndromes 126
Harold J. Olney and Michelle M. Le Beau

8 Chronic myeloid leukemia 153
Thoas Fioretos

9 Chronic myeloproliferative neoplasms 175
Peter Vandenberghe and Lucienne Michaux

10 Acute lymphoblastic leukemia 198
Christine J . Harrison and Bertil Johansson

11 Mature B ] and T ]cell neoplasms and Hodgkin lymphoma 252
Reiner Siebert and Sietse M. Aukema

12 Tumors of the upper aerodigestive tract 332
Susanne M. Gollin

13 Tumors of the lung 361
Penny Nymark, Eeva Kettunen and Sakari Knuutila

14 Tumors of the digestive tract 373
Georgia Bardi and Sverre Heim

15 Tumors of the urinary tract 401
Paola Dal Cin

16 Tumors of the breast 426
Manuel R. Teixeira, Nikos Pandis and Sverre Heim

17 Tumors of the female genital organs 447
Francesca Micci and Sverre Heim

18 Tumors of the male genital organs 481
Manuel R. Teixeira and Sverre Heim

19 Tumors of endocrine glands 497
Jörn Bullerdiek and David Gisselsson

20 Tumors of the nervous system 515
Petter Brandal and Sverre Heim

21 Tumors of the eye 538
Karen Sisley

22 Tumors of the skin 555
Fredrik Mertens, Felix Mitelman and Sverre Heim

23 Tumors of bone 566
Fredrik Mertens and Nils Mandahl

24 Soft tissue tumors 583
Nils Mandahl and Fredrik Mertens

Index 615

Professor Sverre Heim has worked within the field of cancer cytogenetics for more than three decades. He has used chromosomal markers to trace the clonal relationships among neoplastic cell populations and determine their patterns of evolution. He has described numerous specific chromosome abnormalities in various hematologic disorders and solid tumors, identified their gene–level consequences, and has shown that the karyotypic and molecular genetic abnormalities have diagnostic as well as prognostic consequences. Dr Heim has served as a member of several editorial boards and scientific advisory committees. He is the author of nearly 500 scientific publications.

Professor Felix Mitelman has published more than 750 articles in the field of cancer cytogenetics. In the early 1980s, he established a unique database on chromosome changes in cancer a systematic compilation of reported acquired cytogenetic aberrations, the molecular genetic outcome of the cytogenetic abnormalities, and the clinical consequences of the genetic changes. In 1989, Dr Mitelman founded the journal Genes, Chromosomes & Cancer and he has since served as the Editor–in–Chief. He is an elected member of several distinguished societies, including the Royal Swedish Academy of Sciences and the American Academy of Arts and Sciences.