From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products

The biosynthesis of natural products has given knowledge and inspiration to chemists from the beginning of modern synthetic chemistry. Over time, a better understanding of biosynthetic mechanisms has led to the start of biomimetic chemistry in synthesis, biochemical information of enzymic machinery, stereoselective reactions, and advanced synthetic tools. It is crucial for scientists to gain a comprehensive understanding of the importance of biomimetic strategy in total synthesis and biosynthetic mechanisms to improve the productivity and efficiency of organic synthesis.

Focusing on biosynthesis, From Biosynthesis to Total Synthesis provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. The chapters cover the four major biosynthetic routes: acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids. Each of these sections are comprehensive and provide details on biosynthetic mechanisms, description of specific enzymes used for biogenesis and recognition of chemical reactions, and all chemical reactions, tactics, and strategies used to complete the chemical transformations. The final section explains future directions of modern organic synthesis, touching upon engineering biosynthesis, diversity–oriented synthesis, biology–oriented synthesis, and the promise of merging total synthesis with biosynthesis.

From Biosynthesis to Total Synthesis presents strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications. With contributions from leading organic chemists from around the world, the book acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field

Alexandros L. Zografos, PhD, is an Assistant Professor of Chemistry at the Aristotle University of Thessaloniki. He has experience as an organic chemist and has spent several years researching the total synthesis of natural products. Dr. Zografos also teaches graduate and postgraduate courses in Organic Chemistry, Biosynthesis, and Synthesis of Natural Products.