Bioprocessing for Cell–Based Therapies

The robust manufacture and supply of defined cells at commercially relevant scales is a clear requirement for the successful implementation of future cell–based therapy. With contributions from internationally leading academics and industry practitioners, Bioprocessing for Cell–Based Therapies examines both existing industrial methods for the large scale production of a variety of cell types including stem cells as well as recent novel developments in cell culture from the bioprocessing research community.

Covering fermenter designs, 2D and 3D systems, and carrier material, this book also examines the issues around the supply chain, including current best practice and novel means presently under development, along with in–depth discussions on methods used in the delivery of cells to the patient.

Well illustrated, and in full–colour throughout, Bioprocessing for Cell–Based Therapies is the only handbook available that outlines the complete range of cell–based therapies providing a state of the art guide to the field. This text will be invaluable to those working and researching in this area, as well as new postgraduate students.

Chapter 1. Bioprocessing for Cell Based Therapies

Chapter 2. Structured Methodology for Process Development in Scalable Stirred Tank Bioreactors Platforms

Chapter 3. The Effect of Scale–up on Cell Phenotype: Compatibility Testing to Optimize Bioreactor Usage and Manufacturing Strategies

Chapter 4. The Scale–up of Human Mesenchymal Stem Cell Expansion and Recovery

Chapter 5. Challenges of Scale–up of Cell Separation and Purification Techniques

Chapter 6. Fundamental Points to Consider in the Cryopreservation and Shipment of Cells for Human Application

Chapter 7. Short–term Storage of Cells for Application in Cell–based Therapies

Chapter 8. Cell Therapy in Practice

Che Connon, is Professor of Tissue Engineering at the Institute of Genetic Medicine, University of Newcastle upon Tyne, UK; he is also a member of the Bioprocessing Research Industry Club (supported by the BBSRC and EPSRC). His research focuses on seeking to engineer functional replacement and temporary ′bridge′ tissues using a modular approach while also developing model systems to study physiological and pathophysiological corneal tissue formation. He is the author of Corneal Regenerative Medicine (with Bernice Wright, 2013) and Hydrogels in Cell–Based Therapies (with Ian W Hamley, 2014), as well as numerous research papers.