The Handbook of Alzheimers Disease and Other Dementias

This is a broad–ranging review of the current research on Alzheimer′s disease and other dementias from both basic neuroscience and clinical perspectives. It provides scientists and medical professionals with an extensive introduction and an up–to–date review of cutting–edge scientific advances. This reference begins with an introduction to and overview of the major dementias—including Alzheimer′s Disease, Dementia with Lewy Bodies, Frontotemporal Dementia, and Vascular Dementia—and explores pathology, manifestations, treatment, and other necessary background information. The second section explores the state–of–the–art research on specific disease mechanisms relevant to dementia such as neuropathology and epidemiology, and genetic risk factors. The third section examines the most recent research on major topics in cognitive and behavioral neuroscience as it relates to dementia, and the final section explores the latest research in neuroimaging. No other reference encompasses the range of topics presented, or combines basic molecular perspectives and cognitive neurosciences. It is an essential tool for physicians and medical students, psychologists, scientists, and allied health professionals including nurses, social workers, and therapists.

Contributors ix Foreword xii Preface xv Part I Common Dementias 1 1 Alzheimer’s Disease 3 Alan M. Mandell and Robert C. Green 2 Vascular Dementia 92 Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon 3 Dementia with Lewy Bodies 131 Tamara G. Fong and Daniel Z. Press 4 Frontotemporal Dementia 145 Adam L. Boxer 5 Other Dementias 179 Peter Morin Part II Pathogenesis and Disease Mechanisms 195 6 Genetic Risk Factors for Dementia 197 Paul Hollingworth and Julie Williams 7 The Neuropathology of the Dementing Disorders 235 Ann C. McKee and Brandon E. Gavett 8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262 Carmela R. Abraham 9 Other Mechanisms of Neurodegeneration 277 Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki 10 Rational Therapeutics for Alzheimer’s Disease and Other Dementias 301 Neil W. Kowall Part III Cognitive and Behavioral Dysfunction 313 11 Memory Dysfunction in Dementia 315 Andrew E. Budson 12 Language Processing in Dementia 336 Jamie Reilly, Joshua Troche, and Murray Grossman 13 Executive Functioning 369 Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett 14 Emotion and Behavior in Alzheimer’s Disease and Other Dementias 416 Christopher I. Wright 15 Visuospatial Function in Alzheimer’s Disease and Related Disorders 457 Alice Cronin–Golomb 16 Sleep and Circadian Rhythms in Dementia 483 David G. Harper Part IV Neuroimaging in Dementia 505 17 Glimpses of the Living Brain with Alzheimer’s Disease 507 Ronald J. Killiany 18 Functional MRI in Alzheimer’s Disease and Other Dementias 535 Maija Pihlajamäki and Reisa A. Sperling 19 Molecular Neuroimaging of the Dementias 557 Bradford C. Dickerson 20 Using EEG and MEG to Understand Brain Physiology in Alzheimer’s Disease and Related Dementias 575 Brandon A. Ally Index 604 Plate section between pages 304 and 305

Dr. Neil W. Kowall  is Chief of Neurology and Director of the New England GRECC at the VA Boston Healthcare System; he is also Director of the NIH–funded Boston University Alzheimer′s Disease Center, Professor of Neurology and Pathology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He has published over 170 papers in peer–reviewed journals including  Science, Nature , the  Journal of Neuroscience , and the  Annals of Neurology . Dr. Andrew E. Budson is the Deputy Chief of Staff and a member of the Geriatric Research Education Clinical Center (GRECC) at the VA Boston Healthcare System. He is also Associate Director for Research at the Boston University Alzheimer′s Disease Center, Professor of Neurology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He was awarded the 2008 Norman Geschwind Prize in Behavioral Neurology and the 2009 Research Award in Geriatric Neurology, both from the American Academy of Neurology, and has published over 75 papers in peer–reviewed journals including the New England Journal of Medicine , Brain , and Cortex .

“I believe this textbook will be useful to a variety of readers from different backgrounds and at different stages of training and experience and I would be very glad to have it in my library.”  ( International Psychogeriatrics , 25 July 2013)