Skin Lymphoma: The Illustrated Guide

Skin lymphomas are relatively rare but potentially fatal They can easily be misdiagnosed as benign skin diseases. Dermatologists and pathologists need to have a good understanding of the clinical presentations and the pathological correlates of this challenging disease to ensure the correct diagnosis and most appropriate treatment is provided.   Skin Lymphoma: The Illustrated Guide is a full–color illustrated text and atlas that combines pathology with clinical features and treatment. Jam–packed with pictures that illustrate key diagnostic points and supplemented by teaching cases to highlight effective decision making. It includes all newly identified entities and provides pointers on how to differentiate these. In addition, it also covers all inflammatory conditions that may simulate skin lymphomas (cutaneous pseudolymphomas).   Skin Lymphoma: The Illustrated Guide provides   Clinical and pathological guidance on diagnosis of skin lymphomas Clear illustrations to aid visual recognition Nomenclature according to WHO/EORTC classifications Cases to enhance the scope for teaching and learning   This fully refreshed fourth edition continues to provide the clinical excellence that has helped a generation of dermatologists and dermatopathologists to effectively diagnose skin lymphoma.  

1 Introduction Section 1: Cutaneous NK/T–cell Lymphomas 2 Mycosis Fungoides 3 Sézary Syndrome 4 Primary Cutaneous CD30 y Lymphoproliferative Disorders –Lymphomatoid papulosis –Cutaneous anaplastic large cell lymphoma –“Borderline” cases 5 Subcutaneous Panniculitis–like T–cell Lymphoma 6 Aggressive Cutaneous Cytotoxic Lymphomas –Primary cutaneous aggressive epidermotropic CD8 y cytotoxic T–cell lymphoma –Primary cutaneous / Ô T–cell lymphoma –Extranodal NK/T–cell lymphoma, nasal type 7 Cutaneous Peripheral T–cell Lymphoma, Not Otherwise Specified (NOS) 8 Cutaneous CD4+ Small–Medium T–cell Lymphoma –Cutaneous CD4+ Small–Medium T–cell Lymphoma –Indolent CD8+ lymphoid proliferation of the face (ear) –Primary cutaneous T–follicular helper (TFH)–cell lymphoma 9 Cutaneous Adult T–cell Leukemia/Lymphoma 10 Other Cutaneous NK/T–cell Lymphomas –Angioimmunoblastic T–cell lymphoma –Hydroa vacciniforme–like lymphoma Section 2: Cutaneous B–cell Lymphomas 11 Cutaneous Follicle Center Lymphoma 12 Cutaneous Marginal Zone Lymphoma (Cutaneous MALT–lymphoma) and Variants –Cutaneous marginal zone lymphoma, conventional variant –Cutaneous marginal zone lymphoma, lymphoplasmacytic variant –Cutaneous marginal zone lymphoma, plasmacytic variant –Cutaneous marginal zone lymphoma, blastoid variant 13 Cutaneous Diffuse Large B–cell Lymphoma, Leg Type 14 Intravascular Large Cell Lymphomas –Intravascular large B–cell lymphoma –Intravascular large NK/T–cell lymphoma –Intralymphatic CD30+ anaplastic large cell lymphoma 15 Other Cutaneous B–cell Lymphomas –Cutaneous EBV y diffuse large B–cell lymphoma of the elderly –Specific cutaneous manifestations in mantle cell lymphoma –Specific cutaneous manifestations in extracavitary primary effusion lymphoma –Specific cutaneous manifestations in multiple myeloma –Specific cutaneous manifestations in Burkitt lymphoma –Cutaneous lymphomatoid granulomatosis –Cutaneous plasmablastic lymphoma –Cutaneous T–cell/histiocyte–rich B–cell lymphoma Section 3: Cutaneous Lymphomas in Immunosuppressed Individuals 16 Cutaneous Post–transplant Lymphoproliferative Disorders 17 Cutaneous Lymphomas in HIV–infected Individuals 18 Cutaneous Lymphoproliferative Disorders in Other Iatrogenic and Non–iatrogenic Immune Deficiencies Section 4: Specific Cutaneous Manifestations of Leukemias and of Precursor Hematologic Neoplasms 19 Cutaneous Manifestations of B–cell Chronic Lymphocytic Leukemia 20 Cutaneous Manifestations of Myelogenous Leukemia 21 Blastic Plasmacytoid Dendritic Cell Neoplasm 22 Cutaneous Manifestations of Other Leukemias –T–cell prolymphocytic leukemia –Aggressive natural killer cell leukemia –Skin manifestations of other types of leukemia 23 Cutaneous Lymphoblastic Lymphomas –Cutaneous B–lymphoblastic lymphoma –Cutaneous T–lymphoblastic lymphoma Section 5: Cutaneous Manifestations of Hodgkin Lymphoma 24 Cutaneous Manifestations of Hodgkin Lymphoma Section 6: Cutaneous Lymphomas in Children and Adolescents 25 Cutaneous Lymphomas in Children and Adolescents Section 7: Pseudolymphomas of the Skin 26 Pseudolymphomas of the Skin –Actinic reticuloid –Lymphomatoid contact dermatitis –Solitary idiopathic B/T–cell pseudolymphoma –Lichenoid (lymphomatoid) keratosis –Lichen aureus / lichenoid pigmented purpuric dermatitis –Lichen sclerosus –Vitiligo –Annular lichenoid dermatitis of youth –Pseudolymphomatous acrodermatitis chronica atrophicans –Pseudolymphomatous atopic dermatitis –Non–neoplastic erythroderma in adult patients –Pseudolymphomatous cutaneous infiltrates in human immunodeficiency virus (HIV)–infected patients and in other immune deficiencies –CD30+ T–cell pseudolymphomas –Pseudolymphomas in herpes simplex and herpes zoster infections –Epstein–Barr virus (EBV)–associated mucocutaneous ulcers –Hydroa vacciniforme –Pityriasis lichenoides –Pseudolymphomas associated with lupus erythematosus –Lymphomatoid drug reactions –Lymphocytoma cutis –Persistent nodular arthropod bite reactions and nodular scabies –Pseudolymphomas at sites of vaccination –Pseudolymphomas in tattoo –Localized scleroderma / morphea –Cutaneous IgG4–related disease –Pseudolymphomas in syphilis –Cutaneous plasma cell granuloma –Cutaneous and systemic plasmacytosis –Pre–tibial lymphoplasmacytic plaque in children –Cutaneous extramedullary hematopoiesis –Histiocytoid Sweet syndrome –Intralymphatic histiocytosis –Benign intralymphatic proliferation of T–cell lymphoid blasts –Other "accidental" pseudolymphomas –"Malignant" pseudolymphomas Section 8: The Cutaneous “Atypical Lymphoid Proliferation” 27 The Cutaneous “Atypical Lymphoid Proliferation”