Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications

Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, this book enables readers to understand the connection between chemistry and the biological application of bioconjugated materials. Its detailed descriptions of methods make it possible for researchers to fabricate and take full advantage of bioconjugates for a broad range of applications. Moreover, the book sets the foundation for the development of new applications, including assays, imaging, biosensors, drug delivery, and diagnostics. Chemistry of Bioconjugates features contributions from an international team of leading experts and pioneers in the field. These contributions reflect the authors??? firsthand laboratory experience as well as a thorough review of the current literature. The book???s six sections examine: General methods of bioconjugation Polymer bioconjugates Organic nanoparticle–based bioconjugates Inorganic nanomaterial bioconjugates, including metals and metal oxides Cell–based, hydrogel/microgel, and glyco–bioconjugates Characterization, physico–(bio)chemical properties, and applications of bioconjugates This comprehensive exploration of bioconjugates includes discussions of polymers, dendrimers, lipids, nanoparticles, and nanotubes. References at the end of each chapter serve as a gateway to the most important original research findings and reviews in the field. By drawing together and analyzing all the latest chemical methods and research findings on the physico–chemical and biochemical properties of bioconjugates, Chemistry of Bioconjugates sheds new light on the significance and potential of bioconjugation. The book is recommended for organic and polymer chemists, biochemists, biomaterial scientists, carbohydrate chemists, biophysicists, bioengineers, and drug and gene delivery scientists.

SECTION I: GENERAL METHODS OF BIOCONJUGATION CHAPTER 1: COVALENT AND NON–COVALENT BIOCONJUGATION STRATEGIES Rajesh Sunasee and Ravin Narain SECTION II: POLYMER BIOCONJUGATES CHAPTER 2: PEGYLATION Rajesh A. Shenoi, Fang Gao, Muhammad Imran ul–Haq, and Jayachandran N. Kizhakkedathu CHAPTER 3: SYNTHETIC POLYMERS BIOCONJUGATE SYSTEMS Marya Ahmed and Ravin Narain CHAPTER 4: NATURAL POLYMERS  BIOCONJUGATE SYSTEMS Lichao Liu, Xiuwei Pan, and Weian Zhang CHAPTER 5: DENDRIMERS Ali Nazemi and Elizabeth R. Gillies SECTION III: ORGANIC NANOPARTICLES BASED BIOCONJUGATES CHAPTER 6: LIPID, LIPOSOMES, POLYMERSOMES, MICROBUBBLES BIOCONJUGATES Anirban Sen Gupta and Horst A. von Recum CHAPTER 7: ORGANIC NANOPARTICLES BIOCONJUGATES (MICELLES, CROSS–LINKED MICELLES, NANOGELS) Maria Vamvakaki CHAPTER 8: FULLERENE/CARBON NANOTUBES AND GRAPHENE Keshwaree Babooram and Ravin Narain SECTION IV: INORGANIC NANOMATERIALS BIOCONJUGATES (METALS, METAL OXIDES – QUANTUM DOTS, IRON–OXIDE) CHAPTER 9: GOLD NANOMATERIALS BIOCONJUGATES Qian Yang CHAPTER 10: MAGNETIC NANOMATERIALS BIOCONJUGATES Mohammad H. El–Dakdouki, Kheireddine El–Boubbou, Jingguang Xia, Herbert Kavunja and Xuefei Huang CHAPTER 11: QUANTUM DOTS BIOCONJUGATES Xiaoze Jiang, Meifang Zhu and Ravin Narain CHAPTER 12: SILICA NANOPARTICLES Yohei Kotsuchibashi, Mitsuhiro Ebara and Ravin Narain CHAPTER 13: POLYHEDRAL OLIGOMERIC SILSESQUIOXANES (POSS) BIOCONJUGATES Weian Zhang, Zhenghe Zhang, Lizhi Hong SECTION V: CELL–BASED, HYDROGELS/MICROGELS AND GLYCO–BIOCONJUGATES CHAPTER 14: CELL–BASED BIOCONJUGATES Mitsuhiro Ebara CHAPTER 15: BIORESPONSIVE HYDROGELS AND MICROGELS Xue Li and Michael J. Serpe CHAPTER 16: CONJUGATION STRATEGIES USED FOR THE PREPARATION OF CARBOHYDRATE–CONJUGATE VACCINES Rachel Hevey and Chang–Chun Ling SECTION VI: CHARACTERIZATION, PHYSICO–(BIO)CHEMICAL PROPERTIES AND APPLICATIONS OF BIOCONJUGATES CHAPTER 17: PROPERTIES AND CHARACTERIZATION OF BIOCONJUGATES Ali Faghihnejad, Jun Huang and Hongbo Zeng CHAPTER 18: PHYSICO–CHEMICAL AND BIOCHEMICAL PROPERTIES OF BIOCONJUGATES Marya Ahmed and Ravin Narain CHAPTER 19: APPLICATIONS OF BIOCONJUGATES Marya Ahmed and Ravin Narain