Stem Cell Therapeutics for Cancer

A single-source reference on the hot topic of stem cell therapeutics for cancer This work offers a thorough, cohesive look at the state of the art of stem cell therapeutics for cancer, with an emphasis on the unique application of mesenchymal stem cells (MSC) and MSC-like cells as gene-delivery agents in cancer treatment. Edited by a leader in the field, the book brings together a wealth of information from this growing area of research, highlighting topics critical to the success of future therapies, including stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Organized in sections according to disease types, the chapters explore the engineering of specific stem cell types with the protein of interest as well as results from studies of animal models and early-phase clinical trials. The use of cutting-edge molecular imaging techniques for a variety of tumor types is also integrated into the text. Coverage includes: An overview of stem cell types and their fate in models of cancer Stem cell monotherapy in brain cancers, lung cancers, breast cancers, and other malignancies The use of stem cells in combination with other therapies Diagnostic tracking of both stem cells and therapeutic molecules in cancer treatments Possible adverse effects of MSC on tumors, including details on tumor-initiating cells in certain tumor types Clear, concise, and up to date, Stem Cell Therapeutics for Cancer is a must-have resource for scientists and clinicians in stem cell research, cancer therapies, novel drug development, and molecular imaging, and for anyone wishing to learn about the unprecedented potential of stem cell therapeutics for various cancer types.

Contributors vii Preface xi Section 1 Introduction 1 1 Stem Cell Sources and Their Potential for Cancer Therapeutics 3 Khalid Shah Section 2 Migration and Fate of Stem Cells 11 2 The Role of CXCR4 as a Mediator of Glioma–Tropic Neural Precursor Cell Migration 13 Moneeb Ehtesham, Elliot Min, and Rebecca Kasl 3 Tumor Tropism of Mesenchymal Stem Cells 21 Paula Y. P. Lam and Ivy A.W. Ho Section 3 Stem Cell Therapy in Brain Cancer 39 4 Stem Cell–Mediated Trail Therapy for Highly Aggressive Brain Tumors 41 Khalid Shah 5 Stem Cell–Mediated Prodrug Gene Therapy of High–Grade Brain Tumors 57 Cestmir Altaner 6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy 73 Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti S. Rao 7 Stem Cell–Based Antiangiogenic Therapies for Brain Tumors 87 Navid Redjal and Khalid Shah 8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem Cell–Based Oncolytic Virotherapy 103 Manuel Ramírez and Javier García–Castro Section 4 Stem Cell Therapy in Other Cancer Types 111 9 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast Cancer 113 Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer, and Masaaki Tamura 10 Mesenchymal Stromal Cells as Effective Tumor Antigen–Presenting Cells in Cancer Therapeutics 127 Raphaëlle Romieu–Mourez and Jacques Galipeau 11 Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast Cancer Treatment 145 Róisín Dwyer 12 Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy 159 Emily Keung, Peter J. Nelson, and Claudius Conrad 13 Mesenchymal Stem Cells in Prostate Cancer: Clinical Opportunities 171 Diptiman Chanda and Selvarangan Ponnazhagan 14 Primed Mesenchymal Stromal Cells for Cancer Therapy 187 Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini, and Giulio Alessandri Section 5 Combinatorial Stem Cell Therapies 203 15 MicroRNA Adjuvants in Stem Cell–Based Cancer Therapy 205 Maarten C. J. Anderegg and Maarten F. Corsten 16 Stem Cell–Based Combination Therapies for Cancer: Systemic Delivery of a PI3K/mTOR Inhibitor (PI–103) and Stem Cell–Mediated Delivery of TRAIL in Brain Tumors 219 Tugba Bagci–Onder 17 The Efficacy of Clinically Approved Agents with Stem Cell–Delivered Therapeutics for Cancer Therapy 235 Hiroaki Wakimoto and Khalid Shah Section 6 Tracking Stem Cells and Stem Cell–Based Therapeutics 245 18 Imaging Migration and Fate of Stem Cells in Experimental Models of Cancer 247 Deepak Bhere and Khalid Shah 19 Multifunctional Molecules for Interrogating Stem Cell–Based Therapeutics 257 Shawn Hingtgen 20 Tracking Cancer–Targeted MSC with PET Imaging 273 Véronique Roelants and Jean–Louis Vanoverschelde Index 289 Color plate is located between pages 244 and 245.