Immunotherapy in Translational Cancer Research

A guide to state–of–the–art cancer immunotherapy in translational cancer research

A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer–fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues.

Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world???s foremost cancer research and care center and:

Offers a comprehensive presentation of state–of–the–art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy

Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research

Editors, vi

Contributors, vii

Introduction, ix

1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer, 1
Saranya Chumsri and Keith L. Knutson

2 Monoclonal Antibody Therapy, 12
Elizabeth A. Mittendorf and Sabitha Prabhakaran

3 Somatic Mutations and Immunotherapy, 24
Eric Tran

4 Checkpoint Blockade, 37
Tracy A. Proverbs ]Singh, Jedd Wolchok, and Alexandra Snyder

5 Myeloid Leukemia Vaccines, 54
Paul M. Armistead and Jonathan S. Serody

6 Cancer Vaccines for Solid Tumors, 72
Timothy J. Vreeland, Garth S. Herbert, and George E. Peoples

7 Immunotherapy with Non Genetically Modified T Cells, 91
Cassian Yee

8 Immunotherapy with Genetically Modified T Cells, 101
Liora Schultz and Crystal Mackall

9 Immunomodulation with Adjuvants and Cytokines, 115
Dae won Kim and Adi Diab

10 Immune Cell Migration in Cancer and Immunotherapy, 132
Timothy Murray and Daniel E. Speiser

11 Repurposing of Drugs for Immunotherapy, 143
Jyothishmathi Swaminathan and Vidya Gopalakrishnan

12 Immunomodulation with Radiation, 161
Jonathan E. Schoenhals, Taylor R. Cushman, Alexandra P. Cadena, Sandra Demaria, and James W. Welsh

13 Good Manufacturing Practices Facilities for Cellular Therapy, 177
Andrew D. Fesnak and Bruce L. Levine

14 T Cell Receptor Mimic Antibodies, 186
Gheath Alatrash and Jeffrey J. Molldrem

15 Stem Cell Transplantation for Treatment of Malignancy, 201
Lohith S. Bachegowda and Richard E. Champlin

16 Natural Killer Cell Based Immunotherapy, 215
Jennifer A. Foltz, Jeffrey S. Miller, and Dean A. Lee

17 Immunologic Monitoring in Immuno ] Oncology, 228
William R. Gwin and Mary L. Disis

18 Cell ]Based Therapies for Canine Cancer, 252
Nicola J. Mason and M. Kazim Panjwani

19 Interaction between Targeted Therapy and Immunotherapy, 268
Peter A. Prieto, Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo

Index 286

Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA.

Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.

Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA.

Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.