Natural Products in Chemical Biology

A timely and authoritative look at the chemistry of natural products Based on the acclaimed Wiley Encyclopedia of Chemical Biology , this book focuses on natural products and explores their impact on drug discovery and design. With emphasis on the gamut of biological diversity and activities of natural products, the book examines the unique features of these molecules, highlights influences from genetics and biochemistry, and points to promising future trends. Divided into three parts, Natural Products in Chemical Biology first introduces sources of natural products, then goes on to present the biosynthesis of main classes of natural products and their uses in medicine. The book presents fourteen self–contained, peer–reviewed articles carefully selected from the Wiley Encyclopedia of Chemical Biology and new material. Clear, authoritative coverage includes: A discussion of the chemical diversity of plant, marine, and microbial natural products Biosynthesis of nonribosomal peptides, plant terpenoids, polyketides, alkaloids, cofactors, and antibiotics Use of natural products and natural product models in the pharmaceutical industry Natural Products in Chemical Biology is an excellent introduction to the ongoing research in the chemistry of natural products for researchers in diverse fields, from organic and medicinal chemistry to molecular biology and the pharmaceutical industry.

Preface vii Contributors ix PART I CHEMICAL DIVERSITY OF NATURAL PRODUCTS 1 1 Plant Natural Products 3 A. Leslie Gunatilaka 2 Marine Natural Products 31 Nobuhiro Fusetani 3 Microbial Natural Products 65 Sergio Sanchez, Silvia Guzma´n–Trampe, Mariana A´valos, Beatriz Ruiz, Romina Rodr´ýguez–Sanoja, and Manuel Jim´enez–Estrada PART II BIOSYNTHESIS OF NATURAL PRODUCTS 109 4 Nonribosomal Peptides 111 Georg Schoenafinger and Mohamed A. Marahiel 5 Plant Terpenoids 127 Christopher I. Keeling and J¨org Bohlmann 6 Polyketides in Fungi 143 Thomas J. Simpson and Russell J. Cox 7 Modular Polyketide Synthases 163 Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H. Sherman 8 Polyketide Polyethers 189 Alison M. Hill 9 Alkaloids 209 Sarah E. O’Connor 10 Cofactors 239 Ilka Haase, Markus Fischer, Adelbert Bacher, Wolfgang Eisenreich, and Felix Rohdich 11 Antibiotics 269 Sergey B. Zotchev PART III NATURAL PRODUCTS IN MEDICINE 287 12 Pharmaceuticals: Natural Products and Natural Product Models 289 Sheo B. Singh 13 Natural Products as Anticancer Agents 325 David G. I. Kingston and David J. Newman 14 Plant–Derived Natural Products Research in Drug Discovery 351 Kuo–Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L. Morris–Natschke Index 389

NATANYA CIVJAN, PhD , is a freelance editor with a doctorate in biochemistry. Formerly with John Wiley & Sons, she has developed and edited the Wiley Encyclopedia of Chemical Biology and was part of the team responsible for the Wiley Interdisciplinary Reviews , which won top prizes in publishing from the American Publishers Awards for Professional and Scholarly Excellence.

“In summary, this is a really good book from a number of prominent research groups who have made important contributions to their fields.  Some chapters are well suited for newcomers to the subject, as well as for teaching or for reading by interested students.”  ( Angewandte Chemie International Edition , 19 March 2014)