Multicatalyst System in Asymmetric Catalysis

Methods and applications of multicatalyst systems in asymmetric catalysis Asymmetric catalysis plays an important role in the synthesis of chiral compounds, due to their high efficiency and selectivity that traditional methods cannot reach.  This book provides details about the mechanism and advantages of multicatalysis systems in asymmetric catalysis. Examples in this book introduce the difference between multifunctional catalysis and multiple catalyst systems and cover the important and exciting results of multiple catalyst promoted asymmetric reactions and novel tandem reactions. Using examples and step–by–step methods, the chapters cover a variety of pertinent topics including: – Additive–enabled asymmetric metric catalysis – Asymmetric multifunctional catalysis – Asymmetric cooperative catalysis – Asymmetric double activation catalysis, assisted catalysis, photochemical and electrochemical methods – Multicatalyst system realized asymmetric tandem reaction – Waste–mediated Reactions – Multicatalyst system mediated asymmetric reactions in total synthesis In addition, this book focuses on applications and greener ways to make useful substances for pharmaceuticals, agrochemicals, materials, and flavour and fragrance industries.

Preface Contributors Chapter 1 Towards Ideal Asymmetric Catalysis Jian Zhou and Jin–Sheng Yu 1.1 Introduction 1.2 Challenges to Realize Ideal Asymmetric Catalysis 1.3 Solutions 1.4 Borrow ideas from the Nature 1.5 Conclusion Chapter 2 Multicatalyst System Zhong–Yan Cao , Feng Zhu, and Jian Zhou 2.1 Introduction 2.2 Models of Substrate Activation 2.3 Early examples of multicatalyst system mediated asymmetric reactions 2.4 A General Introduction of Multi–catalyst Promoted Asymmetric Reactions 2.5 Classification of Multicatalyst Promoted Asymmetric Reactions 2.6 Challenges and Possible Solutions 2.7 Multicatalyst System vs Multifunctional Catalyst 2.8 Multicatalyst System vs Additive–enhanced Catalysis 2.9 Additive–enhanced Catalysis 2.10 Conclusion References Chapter 3 Asymmetric Multifunctional Catalysis Jin–Sheng Yu and Jian Zhou 3.1 Introduction 3.2 Asymmetric Multifunctional Catalysis 3.3 Asymmetric Hybrid Organo/Metal Catalysis 3.4 Asymmetric Multifunctional Multimetallic Catalysis 3.5 Anion–enabled Bifunctional Asymmetric Catalysis 3.6 Conclusion Chapter 4 Asymmetric Cooperative Catalysis Long Chen, Yu–Lin Liu, and Jian Zhou 4.1 Introduction 4.2 Catalytic asymmetric Michael addition reaction 4.3 Catalytic asymmetric Mannich reaction 4.4 Catalytic asymmetric Conia–Ene reaction 4.5 Catalytic asymmetric umpolung reaction 4.6 Catalytic asymmetric cyanosilylation reaction 4.7 α–Alkylation reaction of carbonyl compounds 4.8 Catalytic asymmetric allylic alkylation reaction 4.9 Catalytic asymmetric aldol–type reaction 4.10 Catalytic asymmetric (aza)Morita–Baylis–Hillman reaction 4.11 Catalytic asymmetric hydrogenation reaction 4.12 Catalytic asymmetric cycloaddition reaction 4.13 Catalytic asymmetric N–H insertion reaction 4.14 Catalytic asymmetric α–functionalization of aldehydes 4.15 Miscellaneous reaction Chapter 5 Asymmetric Double Activation Catalysis by Multicatalyst System Long Chen, Zhong–Yan Cao, and Jian Zhou 5.1 Introduction 5.2 Double activation by aminocatalysis & Lewis base catalysis 5.3 Asymmetric double primary amine & Brønsted acid catalysis 5.4 Asymmetric double metal & Brønsted base catalysis 5.5 Asymmetric H–bond donor catalysis & Lewis base catalysis 5.6 Sequential double activation catalysis 5.7 Conclusion Chapter 6 Asymmetric Assisted Catalysis by Multicatalyst System Xing–Peng Zeng and Jian Zhou 6.1 Introduction 6.2 Asymmetric Assisted Catalysis within Acids and Bases 6.3 Modulation of a metal complex by a chiral ligand 6.4 Supermolecular–type Assisted Catalysis Chapter 7 Asymmetric Catalysis Facilitated by Photochemical or Electrochemical Method Zhong–Yan Cao and Jian Zhou 7.1 Introduction 7.2 Catalytic Asymmetric Reactions Facilitated by Photochemical Method 7.3 Catalytic Asymmetric Reactions Facilitated by Electrochemical Method 7.4 Conclusion References Chapter 8 Multicatalyst System Realized Asymmetric Tandem Reaction Zhou Feng, Yun–Lin Liu, and Jian Zhou 8.1 Introduction 8.2 Multicatalyst Systems of Homocombination 8.3 Hetero combination system realized MSRATR 8.4 Conclusion Chapter 9 Waste–mediated Reactions Jian Zhou and Xing–Ping Zeng 9.1 Introduction 9.2 Historical background 9.3 Waste–Promoted Single Reactions 9.4 By–products as Acidic Promoter 9.5 Waste–promoted Tandem Reactions 9.6 Waste–catalyzed Tandem Reactions 9.7 Conclusions Chapter 10 Multicatalyst System Mediated Asymmetric Reactions in Total Synthesis Yun–Lin Liu and Jian Zhou 10.1 Introduction 10.2 Application of Single Reactions Mediated by Multicatalyst 10.3 Application of Tandem Reactions Mediated by Multicatalyst 10.4 Conclusion

Jian Zhou is a Professor of Chemistry in the Shanghai Key Laboratory of Green Chemistry and Chemical Processes at East China Normal University. He has broad experience in asymmetric catalysis and has published over 30 papers in leading scientific journals after his independent research. Dr. Zhou’s research focuses on the development of new chiral catalysts and catalytic asymmetric reactions for the efficient construction of fully substituted stereogenic carbon centres, as well as economical synthesis and novel tandem reactions.