Greenes Protective Groups in Organic Synthesis

This new 5 th Edition includes updates on protective group chemistry since 2005. Each chapter is updated to reflect the new material that has been published since the last edition, totalling over 2800 references. This continues the tradition of Greene’s being comprehensive in the overall scope of coverage, providing the most relevant and useful examples to illustrate each methodology. Greene’s Protective Groups is a useful guide to the organic chemist, and the content is organized on the basis of the functional group to be protected (i.e., ethers, amides, phenols, phosphates, etc). Within each section, the organization goes from the simple protective groups to the most complicated (in terms of structure).

Preface to the Fifth Edition Preface to the Fourth Edition Preface to the Third Edition Preface to the Second Edition Preface to the First Edition Abbreviations 1. The Role of Protective Groups in Organic Synthesis 2. Protection for the Hydroxyl Group, Including 1,2– and 1,3–Diols Ethers Esters Protection for 1,2– and 1,3–Diols 3. Protection for Phenols and Catechols Protection for Phenols Protection for Catechols Protection for 2–Hydroxybenzenethiols 4. Protection for the Carbonyl Group Acetals and Ketals Miscellaneous Derivatives Monoprotection of Dicarbonyl Compounds 5. Protection for the Carboxyl Group Esters Amides and Hydrazides 6. Protection for the Thiol Group Thioethers Thioesters Miscellaneous Derivatives 7. Protection for the Amino Group Carbamates Amides Special –NH Protective Groups Protection for Imidazoles, Pyrroles, and Indoles Protection for Amides 8. Protection for the Alkyne –CH 9. Protection for the Phosphate Group Some General Methods of Phosphate Ester Formation Removal of Protective Groups from Phosphorous Alkyl Phosphates Phosphates Cleaved by Cyclodesesterification Benzyl Phosphates Phenyl Phosphates Photochemically Cleaved Phosphate Protective Groups Amidates Miscellaneous Derivatives 10. Reactivities, Reagents, and Reactivity Charts Reactivities Reagents Reactivity Charts Index

Peter G.M. Wuts is a Distinguished Scientist at Kalexsyn, Inc. in Kalamazoo, Michigan.