Advances in Enzymology and Related Areas of Molecular Biology, Volume 78

Analyzes the latest advances in mechanistic enzymology
Volume 78
Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological processes, and their applications in both the laboratory and industry.
Each volume in the series features contributions by leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability.
Volume 78 focuses on the transglutaminase family of enzymes from the perspective of biochemistry (structure and activity), human disease, and inhibition for therapeutic intervention. The transglutaminases, first described in 1957, are a large, widely distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains.? The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
With its wide range of topics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.

Spis treści:
Contributors vii
Preface ix
Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functi ons and Pathological Roles 1
Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin
Physiopathological Roles of Human Transglutaminase 2 47
Vittorio Gentile
Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross–Linking Substrate 97
Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian
Transglutaminase 2: A New Paradigm for NF–B Involvement in Disease 161
Soo–Youl Kim
Transglutaminase 2 At the Crossroads between Cell Death and Survival 197
Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo
Tissue Transglutaminase and Its Role in Human Cancer Progression 247
Bo Li, Richard A. Cerione, and Marc Antonyak
Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295
Zsuzsa Szondy, Ilma Korponay–Szabo, Robert Kiraly, and Laszlo Fesus
Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347
Zoltan Nemes
Transglutaminase–Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385
Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti
Irreversible Inhibitors of Tissue Transglutaminase 415
Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin
Methionine Adenosyltransferase (S–Adenosylmethionine Synthetase) 449
Marıa A. Pajares and George D. Markham
Index 523

Nota biograficzna:
Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic an d biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency—Energy (ARPA–E) of the Department of Energy and directs ARPA–E′s electrofuels program.

Okładka tylna:
Analyzes the latest advances in mechanistic enzymology
Volume 78
Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological processes, and their applications in both the laboratory and industry.
Each volume in the series features contributions by leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability.
Volume 78 focuses on the transglutaminase family of enzymes from the perspective of biochemistry (structure and activity), human disease, and inhibition for therapeutic intervention. The transglutaminases, first described in 1957, are a large, widely distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains.? The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
With its wide range of to pics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.