Oxidative Stress and Cardiac Failure

Far from being a direct complication of primary damage to heart muscle, it is now recognised that the pathogenesis of heart failure may rely on a combination of neurohormonal, cellular and molecular factors. An overwhelming number of systems appear to be activated in heart failure and contribute in some way towards structural remodelling.
Comprising a comprehensive evaluation of the experimental and clinical data relating oxidative stress and heart failure, this text proposes that oxidative stress may be the common pathway for muscle dysfunction, cellular growth and remodelling, and mytocyte death. Acknowledged experts in the field here present a persuasive argument for raising the profile of oxidative stress as an important, perhaps critical contributor to the adverse consequences of heart failure. This volume should serve as a rich source of supportive data for clinicians and investigators interested in the pathophysiology and treatment of heart failure, and as a platform on which to base further research.

Spis treści:
Foreword: Jay N. Cohn .
Introduction: Marrick L. Kukin.
Contributors.
Abbreviations Used in This Book.
I. Current Concepts in Heart Failure.
1. Natural History of Heart Failure.
W.H. Wilson Tang and Gary S. Francis.
2. Pathophysiology of Chronic Heart Failure.
Tatiana Tsvetkova and Michael R. Bristow.
II. Pathophysiology, Clinical, and Laboratory Evidence of Oxidative Stress in Heart Failure.
3. Chemistry of Free Radicals in Biological Systems.
Jay L. Zweier and Frederick A. Villamena.
4. Evidence of Oxidative Stress in Heart Failure.
Kenneth Y.K. Wong, Allan D. Struthers, and Jill J.F. Belch.
5. Animal Models: Apoptosis and Oxidative Stress.
Hani N. Sabbah and Elaine J. Tanhehco.
6. Oxygen Free Radicals, Iron, and Cytokines in Heart Failure: From Bench to Bedside.
Mona Shawky, Neelam Khaper, and Peter Liu.
7. Adrenergic and Mechanical Regulation of Oxidative Stress in the Myocardium.
Deborah A. Siwik, David R. Pimentel, Lei Xiao, Krisha Singh, Douglas B. Sawyer, and Wilson S. Colucci.
III. Therapeutic Pathways and Modulation of Oxidative Stress.
8. Beta–Blockers and Oxidative Stress.
Marrick L. Kukin.
9. Angiotensin–Converting Enzyme Inhibitors and Oxidative Stress.
Balkrishna Singh and William T. Abraham.
10. Angiotensin II Receptor Blockers and Oxidative Stress.
Colin Berry and John McMurray.
11. Microvasculature and Oxidative Stress, With Special Emphasis on the Acute Coronary Syndromes.
Mardi Gomberg–Maitland and Valentin Fuster.
12. The Role of Reactive Oxygen Species in the Pathogenesis of Endothelial Dysfunction in Patients with Chronic Heart Failure.
Haoyi Zheng, Henry Krum, and Stuart D. Katz.
13. Antioxidant Vitamins and Apoptosis.
Fuzhong Qin and Chang–seng Liang.
Index

Okładka tylna:
Far from being a direct complication of primary damage to heart muscle, it is now recognised that the pathogenesis of heart failure may rely on a combination of neurohormonal, cellular and molecular factors. An overwhelming number of systems appear to be activated in heart failure and contribute in some way towards structural remodelling.
Comprising a comprehensive evaluation of the experimental and clinical data relating oxidative stress and heart failure, this text proposes that oxidative stress may be the common pathway for muscle dysfunction, cellular growth and remodelling, and mytocyte death. Acknowledged experts in the field here present a persuasive argument for raising the profile of oxidative stress as an important, perhaps critical contributor to the adverse consequences of heart failure. This volume should serve as a rich source of supportive data for clinicians and investigators interested in the pathophysiolo gy and treatment of heart failure, and as a platform on which to base further research.