Chronic Graft Versus Host Disease

Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

Spis treści:
Part I. General Principles
1. History Alois Gratwohl
2. Pathophysiology of acute GVHD Carrie Kitko and James L. M. Ferrara
3. Pathophysiology of chronic GVHD Kirk Schultz
4. Animal models of chronic GVHD Yu-Wayne Chu, Ronald Gress, and Warren D. Shlomchik
5. Incidence and trends Sally Arai, Mukta Arora, and Douglas Rizzo
6. Clinical manifestations and natural history Mary Evelyn D. Flowers and Georgia Vogelsang
7. Risk factors and predictive models Görgün Akpek and Stephanie J. Lee
8. Biomarkers in prediction and monitoring Ernst Holler and Anne Dickinson
Part II. Clinical Management
9. Diagnosis and staging Madan Jagasia, Howard M. Shulman, Alexandra H. Filipovich, and Steven Pavletic
10. Chronic GVHD pharmacology and commonly used drugs T. Hughes and Timothy McGuire
11. Prevention of chronic GVHD Andrea Bacigalupo and Nelson J. Chao
12. Front line treatment of chronic GVHD Paul J. Martin and Andrew L. Gilman
13. Salvage treatment of chronic GVHD Hildegard T. Greinix and Joseph H. Antin
14. Response measurement David Jacobsohn, Sandra A. Mitchell, and Steven Z. Pavletic
15. General principles in ancillary and supportive care Paul A. Carpenter and Dan R. Couriel
Part III. Organ Site or System Specific Manifestations
16. Skin Edward W. Cowen and Sharon R. Hynes
17. Mouth Nathaniel S. Treister, Mark M. Schubert, and Jane M. Fall-Dickson
18. Eyes Stella K. Kim, Janine A. Smith, and James P. Dunn Jr.
19. Genitalia Maria L. Turner and Pamela Stratton
20. Gastrointestinal (including nutritional support) Miwa Sakai and George B. McDonald
21. Pulmonary Javier Bolaños-Meade and Jason W. Chien
22. Hematologic Corey Cutler
23. Neurologic Harry Openshaw
24. Musculoskeletal Li Li, Leighton Chan, and Lynn H. Gerber
25. Infections Juan Gea-Banacloche and Michael Boeckh
26. Metabolic and endocrine effects Paul A. Carpenter and Jean E. Sanders
27. Other manifestations Kristin Baird and Andrew L. Gilman
28. Psycho-social issues Loretta Williams and Karen L. Syrjala
29. Secondary and late effects Gérard Socié and H. J. Deeg
30. Quality of life assessments Sandra A. Mitchell and Bryce B. Reeve
Part IV. Special Considerations in Chronic GVHD
31. Clinical trials design Paul J. Martin, Donna Przepiorka, and Stephanie J. Lee
32. Unique clinical situations Mohamad Mohty, Juliet N. Barker, and Claudio Anasetti
33. Pediatric chronic GVHD Kristin Baird, Alan S. Wayne, and David A. Jacobsohn
34. Coordination and continuity of interdisciplinary practice Viki Anders, Carina Moravec, and Sandra A. Mitchell
35. Patient and family education, advocacy, and support groups Kathleen M. Castro, Susan Stuart, Myra J. Jacobs, and Paula Kim
36. Future directions Stephanie J. Lee.