Blood Disorders in the Elderly

The developed world has an increasingly aging population, with approximately 10% of the population aged over 65 years. As the incidence and prevalence of blood disorders increases with age, these conditions are a heavy burden on healthcare systems. Blood Disorders in the Elderly will provide hematologists, geriatricians and all clinicians involved in the care of patients with blood disorders with clear clinical advice on the diagnosis and management of these conditions. The introductory section reviews epidemiology of aging and anemia and provides a comprehensive approach to the management of cancer in the aging patient. This is followed by a full discussion of hemopoiesis and changes it undergoes in aging. The remaining sections cover the diagnosis and management of all major disorders: anemia, malignancy, coagulation and platelet disorders and hemophilia. A detailed chapter on antithrombotic therapies is also included.

Spis treści:
Introduction
Part I. Epidemiology
1. Epidemiology of aging Lodovico Balducci and William B. Ershler
2. Epidemiology of anemia, older adults Kushang V. Patel and Jack M. Guralnik
3. Cancer in the older person, a comprehensive approach Oscar A. Cepeda, Julie K. Gammack and John E. Morley
4. From fitness to frailty, toward a nosologic classification of the older aged person Lodovico Balducci and Claudia Beghe
Part II. Hemopoiesis
5. Stem cell exhaustion and aging Gary Van Zant
6. Hemopoietic micro-environment and age David N. Haylock and Susan K. Nilsson
7. Replicative senescence, aging, and cancer Rita Effros
8. Qualitative changes of hemopoiesis France Laurencet and Gilbert Zulian
9. Aging and hemopoietic stress Lodovico Balducci and Cheryl Hardy
10. Immunoglobulin response and aging Yuping Deng and Stefan Gravenstein
11. Biological and clinical significance of monoclonal gammopathy Arati V. Rao and Harvey J. Cohen
Part III. Anemia of Aging
12. Erythropoietin and aging Andrew S. Aartz
13. Iron and aging E. Nemeth and Tomas Ganz
14. Prevalence and mechanism of B12 deficiency Sally P. Stabler
15. The consequences of anemia Luigi Ferrucci and Dan L. Longo
16. The pathogenesis of late-life anemia Bindu Kanapuru and William B. Ershler
17. Treatment of late-life anemia William B. Ershler
Part IV. Hematological Malignancies and Aging
18. Cancer chemotherapy in the older person Lodovico Balducci
19. Acute myeloid leukemia in the elderly Magda Elkabani and Jeffrey Lancet
20. Acute lymphoblastic leukemia in elderly patients, diagnosis and therapy Salvatore Bruno, Femina Mazzella and Oscar Ballester
21. Multiple myeloma Todd J. Alekshun and Melissa Alsina
22. Non-Hodgkin lymphoma Nicole Jacobi and Bruce A. Peterson
23. Unusual lymphomas in the elderly Youssef Gamal, Samuel Kerr and Thomas P. Loughran
24. Chronic lymphocytic leukemia in the elderly Alexander S. D. Spiers
25. Polycythemia vera and idiopathic myelofibrosis in the elderly Jerry L. Spivak
Part V. Disorders of Hemostasis in the Elderly
26. Acquired hemophilia in the elderly F. Baudo and F. de Cataldo
27. Blood coagulation and aging Jozef Vermylen and Marc F. Hoylaerts
28. Platelet disorders in the elderly Laura Terranova, Giancarla Gerli and Marco Cattaneo
29. Gene-environment interactions and vascular risk in the elderly Daniela Mari
30. Antithrombotic therapy, guidelines for the elderly Chiara Cerletti, H. J. Schunemann and Giovanni de Gaetano.