Pharmacogenetics of Psychotropic Drugs

Pharmacogenetics and pharmacogenomics are areas of rapidly growing importance at the interface of molecular genetics and psychopharmacology, with implications for drug development and clinical practice. This book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the findings that have already emerged. Coverage extends to antipsychotics, antidepressants, mood stabilizing, cognitive-enhancing and anxiolytic drugs. Chapters also examine the interface of pharmacogenetics with substance dependence and brain imaging, and consider its impact on the biotechnology and pharmaceutical industries. This book defines the young field of pharmacogenetics as it applies to psychotropic drugs, and is therefore an essential reference for all clinicians and researchers working in this field.

Spis treści:
Part I. Introduction
1. Genes and psychopharmacology, exploring the interface Bernard Lerer
Part II. Clinical Background and Research Design, 2. From pharmacogenetics to pharmacogenomics of psychotropic drug response Anil K. Malhotra
3. Neuropsychopharmacology, the interface between genes and psychiatric nosology Thomas A. Ban
4. Methodological issues in psychopharmacogenetics Sheldon H. Preskorn
5. Statistical approaches in psychopharmacogenetics Fabio Macciardi
Part III. Molecular Background
6. The psychopharmacogenetic-neurodevelopmental interface in serotonergic gene pathways K. Peter Lesch, Jens Benninghoff and Angelika Schmitt
7. RNA processing regulation and interindividual variation Colleen M. Niswender and Linda K. Hutchinson
Part IV. Pharmacokinetics
8. Pharmacogenetics of psychotropic drug metabolism Vural Ozdemir, Angela D. M. Kashuba, Vincenzo S. Basile and James L . Kennedy
9. Pharmacogenetics of chiral psychotropic drugs Pierre Baumann and Chin B. Eap
Part V. Specific Psychotropic Drugs and Disorders
10. Clozapine response and genetic variation in neurotransmitter receptor targets David A. Collier, Maria J. Arranz, Sarah Osborne, Katherine J. Aitchison, Janet Munro, Dalu Mancama and Robert W. Kerwin
11. Genetic factors underlying drug-induced tardive dyskinesia Ronnen H. Segman and Bernard Lerer
12. Functional gene-linked polymorphic regions in pharmacogenetics Marco Catalano
13. Alternative phenotypes and the pharmacogenetics of mood and anxiety disorders Emanuela Mundo and James L. Kennedy
14. Pharmacogenetics of anxiolytic drugs and the GABA-benzodiazepine receptor complex Smita A. Pandit, Spilios V. Argyropoulous, Patrick G. Kehoe and David J. Nutt
15. Genetic factors and long-term prophylaxis in bipolar disorder Martin Alda
16. Genetic influences on responsiveness to anticonvulsant drugs Thomas N. Ferraro
17. Apolipoprotein E as a marker in the treatment of Alzheimers disease Keith Schappert, Pierre Sevigny and Judes Poirier
18. Genetic variation and drug dependence risk factors Joel Gelernter and Henry Kranzler
Part VI. Pharmacogenetics and Brain Imaging
19. Brain imaging and pharmacogenetics in Alzheimers disease and schizophrenia Steven G. Potkin, James L. Kennedy and Vincenzo S. Basile
Part VII. Industry perspectives
20. Pharmacogenetics in psychotropic drug discovery and development William Z. Potter, AnnCatherine Van Lone and Larry Altstiel
21. High-throughput single nucleotide polymorphism genotyping Anne Shalom and Ariel Darvasi
Index.