Biology and Pathology of the Oocyte

The human oocyte or egg is the rarest and most rapidly ageing cell in the body, and yet one that is essential for fertility. This book is about the development, biology and pathology of the oocyte, and new technologies to manipulate, enhance, and control fertility. These technologies are paving the way for overcoming infertility, avoiding inherited diseases, and creating genetically engineered animals from embryo stem cells and cloning. This progress would have been impossible without the myriad of scientific and technical developments covered in this book, including the ability to manipulate and fertilize oocytes in vitro. World-leading experts have contributed to the first book for many years on basic and applied science of the egg, its clinical manipulation, and its pivotal role in reproductive medicine and biology. It will be an essential reference for scientists and clinicians in reproductive medicine and animal breeding technology, and everyone involved in treating infertility.

Spis treści:
Preface
Part I. Historical Perspective
1. The magic and mystery of the oocyte, ex ovo omnia Roger Short
Part II. Life Cycle
2. Ontogeny of the mammalian ovary Anne Grete Byskov and Majken Neilsen
3. The early stages of follicle growth Alain Gougeon
4. Modelling the dynamics of ovarian follicle utilisation throughout life M. J. Faddy and Roger Gosden
5. Comparative aspects of oogenesis Mary Bownes and Stephen Pathirana
Part III. Developmental Biology
6. Oocyte-specific gene expression, roles in folliculogenesis, fertilization and early development Jurrien Dean
7. Morphology and pathology of the human oocyte A. Henry Sathananthan
8. Storage and functional recovery of molecules in oocytes V. Duranthon and J. P. Renard
9. Endocrine regulation of meiosis - local and systemic hormonal influences J. K. Findlay
10. Checkpoint controls in mammalian oocytes Yanfeng Dai, Robert Moor and Josef Fulka Jr
11. Fertilization, fate of sperm components after ICSI Laura Hewitson, Joao Ramalho-Santos, Calvin Simerly and Gerald Schatten
12. Activation of the mammalian egg Philippe Collas and Rafael Fissore
13. Clinical application of symmetry, asymmetry and polarity in early human development Jonathan Van Blerkom
Part IV. Pathology
14. The legacy of mitochondrial DNA Eric A. Shoubridge
15. Aneuploidy in ageing oocytes and after toxic insult Ursula Eichenlaub-Ritter
16. Genetic basis of primary ovarian failure Gerard S. Conway and Sophie Christin-Maitre
Part V. Technology and Clinical Medicine
17. Growth and development of the mammalian oocyte-granulosa cell complex in culture John J. Eppig
18. Human oocyte maturation in vitro Alan Trouson
19. Follicular factors affecting oocyte maturation and development competence Marc-André Sirard
20. Low temperature storage of follicular and ovulated oocytes Roger G. Gosden
21. Fecundity of transplanted ovaries J. M. Shaw
Index.