Nitric Oxide in Bone and Joint Disease

Nitric oxide research has emerged as one of the most important and new areas in bone and joint diseases. This book is the first one to draw together current knowledge on the actions of this mediator and its role in such common diseases as arthritis and osteoporosis. It introduces the basic biology and biochemistry of nitric oxide, the immune response and bone biology. It reviews in depth the facts we know today and the future promise of this exciting area of research. The book will give scientists and clinicians a unique insight into this increasingly important area. It also emphasises potential new treatments which exploit our understanding of the role of nitric oxide in bone and joint disease.

Spis treści:
Foreword Julia M. Polak
Part I. Nitric Oxide and Cytokines, An Introduction
1. A brief overview of the biology of nitric oxide P. Vallance and S. Moncada
2. Nitric oxide and immune responses I. B. McInness and F.Y. Liew
3. Bone biology and pathophysiological mechanisms of bone disease R. G. G. Russell, P. Croucher, B. Oyajobi, S Rahman, M. Rogers and A. Scutt
Part II. Nitric Oxide in Arthritis
4. Nitric oxide and blood flow in arthritis J. C. Lockhart, L. McMurdo and W. R. Ferrell
5. Effects of nitric oxide synthase inhibitors in experimental models of arthritis C. H. Evans and M. Stefanovic-Racic
6. Nitric oxide and prostaglandin interactions in acute and chronic inflammation D. Salvemini
7. Nitric oxide and cartilage matrix turnover M. Cao, H. J. Hauselmann, M. Stefanovic-Racic and C. H. Evans
8. Nitric oxide production in human inflammatory arthritides N. Miyasaka and Y. Hirata
9. The complex influences of reactive oxygen species on rheumatoid erosions and synovitis J. M. Kanczler, T. Sahinoglu, C. R. Stevens and D. R. Blake
Part III. Nitric Oxide, Bone Cell Function and Osteoporosis
10. Nitric oxide and osteoblast function F. J. Hughes, L. D. K. Buttery, M. V. J. Hukkanen and J. M. Polak
11. Nitric oxide as a mediator of cytokine effects on bone S. H. Ralston
12. The osteoclast, bone homeostasis and postmenopausal osteoporosis L. Mancini, N. Moradi-Bidhendi and I. MacIntyre
Part IV. Nitric Oxide and Mechanical Factors
13. Modulation of bone blood flow by nitric oxide I. D. McCarthy
14. Fluid shear stress T. N. McAllister and J. A. Frangos
15. Mechanical strain-associated nitric oxide production by bone cells A. A. Pitsillides and L. E. Lanyon
16. The response of bone and bone cells to mechanical stimulation T. J. Chambers, J. W. M. Chow, S. Fox, R. L. Howard, C. J. Jagger, J. M. Lean, F. T. Mitchell and R. Smalt
17. Aseptic loosening of total hip prostheses S. A. Corbett, M. V. J. Hukkanen, S. P. F. Hughes and J. M. Polak
Index.