Genomic Imprinting

This significant new publication on genomic or parental imprinting has been prepared by an outstanding team of international authorites. Genomic imprinting results in the preferential expression of one allele, depending on the parent of origin. It is associated with several disease syndromes in humans. Interest in this area has expanded rapidly from the time when it was first recognised that some aspects of inheritance were not adequately explained by the Mendelian laws. The chapters cover a wealth of material to help explain not only the mechanisms of genomic imprinting but also its biological and medical consequences. This interdisciplinary volume encompasses clinical genetics, pathology, developmental biology, evolution and genetics. It will be an essential resource for all scientists and clinicians working in this area.

Spis treści:
Contributors
Part I. Genomic Imprinting in Mammals
1. The role of imprinting in early mammalian development A. Gilligan, and D. Solter
2. The evolution of parental imprinting, a review of hypotheses D. Haig and R. Trivers
3. Genetic variations in parental imprinting on mouse chromosome 17 J. Forejt, S. Gregorovà, M. Landíková, J. Capková and L. M. Silver
Part II. Chromatin Structure and DNA Modifications
4. Epigenetic inheritance, the chromatin connection A. P. Wolffe
5. Chromobox genes and the molecular mechanisms of cellular determination P. B. Singh and T. C. James
6. The biochemical basis of allele-specific gene expression in genomic imprinting and X inactivation T. H. Bestor
7. DNA methylation and mammalian development R. Jaenisch, C. Beard and E. Li
Part III. Mechanisms of Imprinting
8. X chromosome inactivation and imprinting M. F. Lyon
9. Imprinting of H19 and Xist in uniparental embryos M. A. Surani, A. C. Ferguson-Smith, H. Sasaki and S. C. Barton
10. Imprinted genes, allelic methylation, and imprinted modifiers of methylation W. Reik, R. Feil, N. D. Allen, T. F. Moore and J. Walter
11. Genomic imprinting of the H19 and Igf2 genes in the mouse S. M. Tilgham, M. S. Bartolomei, A. L. Webber, M. E. Brunkow, J. Saam, P. A. Leighton and K. Pfeifer
12. Plasticity of imprinting R. Ohlsson, T. Ekström, G. Franklin, S. Pfeifer-Ohlsson, H. Cui, S. Miller, R. Fisher and C. Walsh
13. Regional regulation of allele-specific gene expression I. Simon and H. Cedar
Part IV. Genomic Imprinting in Embryonal Tumors and Overgrowth Disorders
14. Genomic imprinting in embryonal tumors and overgrowth disorders A. E. Reeve
15. Tracking imprinting, the Beckwith-Wiedemann syndrome M. Mannens
16. Genomic imprinting in Beckwith-Wiedemann syndrome R. Weksberg and J. Squire
17. Mitotic crossing over and the disruption of genomic imprinting G. B. Côté
18. Evaluating H19 as an imprinted tumor suppressor gene B. Tycko
19. A domain of abnormal imprinting in human cancer A. P. Feinberg
Part V. Genomic Imprinting and the Prader-Willi Syndrome
20. Parent-of-origin-specific DNA methylation and imprinting mutations on human chromosome 15 B. Horsthemke, B. Dittrich and K. Buiting
21. The SNRPN gene and Prader-Willi syndrome U. Francke, J. A. Kerns and J. Giacalone
Part VI. Imprinting, A Search for New Genes and Unifying Principles
22. Use of chromosome rearrangements for investigations into imprinting in the mouse B. M. Cattanach, J. Barr and J. Jones
23. A new imprinted gene, U2af-related sequence, isolated by a methylation-sensitive genome scanning method T. Mukai, I. Hatada, T. Yamaoka, K. Kitagawa, X.-D. Wang, T. Sugama, J. Masuda and J. Ogata
24. The mouse Igf2/MPR gene, a model for all gametic imprinted genes? D. P. Barlow
Index.