New Therapies for Neonatal Respiratory Failure

The diagnosis and treatment of respiratory problems in the newborn have advanced significantly over recent years, although respiratory failure remains an important cause of neonatal mortality and morbidity. This book provides a comprehensive overview of respiratory physiology in the newborn, and of the mechanism underlying respiratory failure in this age group. It goes on to present in detail the techniques, both novel and well established, for effective ventilatory support. In presenting and evaluating the available treatment modalities, the authors consider not only clinical indications, modes of delivery and monitoring, but also complications and outcomes. Comprehensive and up to date, this is an essential handbook and reference for clinicians in neonatal medicine, that will help to optimise their management of respiratory failure in the newborn.

Spis treści:
Part I. Surfactant
1. Composition and structure of pulmonary surfactant Jeffrey A. Whitset
2. Surfactant function and metabolism Alan H. Jobe
3. Surfactant inactivation Machiko Ikegami
4. Surfactant in the prevention and treatment of respiratory distress syndrome Roger F. Soll, T. Allen Merritt and Millo Hallman
5. Lung surfactant replacement for neonatal pathology other than primary respiratory distress syndrome Jonathan M. Davis and Robert H. Notter
Part II. Mechanical Ventilation
6. The mechanics of breathing Gregory P. Heldt
7. Pulmonary gas exchange, basic principles and the effects of mechanical ventilation Bruce R. Boynton and Michael D. Hammond
8. Advances in conventional mechanical ventilation Waldemar A. Carlo, Anne Greenhough and Robert L. Chatburn
9. Patient initiated mechanical ventilation Gregory P. Heldt and Graham Bernstein
10. Physiologic monitoring M. Douglas Cunningham
11. Oscillatory mechanics, the pressure cost of high frequency ventilation Jose F. Venegas and Jeffrey J. Fredberg
12. Pulmonary gas exchange during high frequency ventilation Bruce R. Boynton and Waldemar A. Carlo
13. High frequency oscillatory ventilation and high frequency flow interruption Patricio Fernandez-Martorell and Bruce R. Boynton
14. High frequency jet ventilation Carl H. Coghill, Waldemar A. Carlo and Richard J. Martin
15. Negative pressure ventilation Eduardo Bancalri
16. Techniques of oxygenation and ventilation with continuous gas flow Jesus Villar and Arthur S. Slutsky
17. Liquid ventilation Thomas H. Shaffer, Jay S. Greenspan and Marla R. Wolfson
Part III. Extracorporeal Membrane Oxygenation
18. Extracorporeal respiratory assist for acute respiratory failure Kyoji Tsuno and Theodor Kolobow
19. Clinical use of ECMO Billie Lou Short
Part IV. Nitric Oxide Inhalation
20. Physiology of nitric oxide in the perinatal lung Jesse D. Roberts and Steven H. Abman.