Enantiocontrolled Synthesis of Fluoro–Organic Compounds: Stereochemical Challenges and Biomedical Targets

Fluorinated organic compounds are well known for their unusual reactivity but fluorine can also dramatically influence the stereochemical outcome of reactions providing a challenge to organic synthetic chemists. Enantiocontrolled Synthesis of Fluoro–organic Compounds is a comprehensive review of the methods for preparing stereochemically defined fluorine–containing compounds. This is the first book devoted to stereochemical aspects of fluorine chemistry and contains:detailed reviews on stereocontrolled synthesis of biologically important compounds21 chapters covering the main areas of asymmetric synthesis and biocatalysis where fluorine plays a key rolemechanisms and methods for synthesizing fluoro–organic compounds.Written for professionals involved in organic, physical and organofluorine chemistry, natural product synthesis, biological, pharmaceutical and other life science related industries.

Spis treści:
1. Asymmetric Fluorination
2. Asymmetric of Fluoroalkylation
3. Synthesis of Stereochemically Defined Fluoro–Organic Compounds vi Dehydroxy–Fluorination and Related Reactions
4. Asymmetric Synthesis of Fluoro–Organic Compounds via Chiral Sulfoxide Chemistry
5. Synthesis of Stereochemically Defined Trifluoromethyl–Containing Compounds from (S)–3,3,3–Trifluoropropene Oxide
6. Asymmetric Reduction of Fluorine–Containing Carbonyl Compounds
7. Asymmetric Aldol Reactions of Fluoro–Carbonyl Compounds
8. Asymmetric Michael Addition of Reactions of Fluorocarbons
9. Asymmetric Oxidation of Fluoro–Olefins
10. Biocatalytic Approach to Enantiomerically Enriched Fluoro–Organic Compounds
11. Stereocontrolled Syntheses of Fluorinated Carbohydrates
12. Asymmetric Synthesis of Fluoro–amino acids
13. Chiral non–racemic Fluorinated Nucleosides –
Recent Synthetic Methods
14. Asymmetric Syntheses and Reso lutions of Fluorinated Volatile Anesthetics
15. Fluorine–Containing Chiral Auxiliaries and Ligands for General Asymmetric Synthesis
16. Fluorine–Containing Agents for Determining Enantiomeric Excess of Chiral Molecules
17. Fluorine–Containing Chiral Liquid Crystals: Syntheses and Properties
18. Synthesis of Enantiopure alpha–Trifluoromethyl Alcohols via Chiral Lewis Acid–Catalyzed Carbonyl–Ene Reactions and their Application in the Design of New Liquid Crystals
19. Coordination Ability of Fluorine to Proton or Metals Based on Experimental and Theoretical Evidence
20. Physical and Structural Size of Fluorine in Fluoro–Organic Compounds
21. The Chemical and Physiological Size of Fluorine

Okładka tylna:
Fluorinated organic compounds are well known for their unusual reactivity but fluorine can also dramatically influence the stereochemical outcome of reactions providing a challenge to organic synthetic chemists. Enantiocontrolled Synthesis of Fluoro–organic Compounds is a comprehensive review of the methods for preparing stereochemically defined fluorine–containing compounds. This is the first book devoted to stereochemical aspects of fluorine chemistry and contains:detailed reviews on stereocontrolled synthesis of biologically important compounds21 chapters covering the main areas of asymmetric synthesis and biocatalysis where fluorine plays a key rolemechanisms and methods for synthesizing fluoro–organic compounds.Written for professionals involved in organic, physical and organofluorine chemistry, natural product synthesis, biological, pharmaceutical and other life science related industries.