Gastroenteritis Viruses

Gastroenteritis viruses are a major cause of morbidity and mortality in humans. Many hundreds of thousands of children die annually from rotavirus diarrhoea in the developing world, and although in industrialized countries rotavieus infection is rarely fatal, the economic burden of the disease is substantial. Human caliciviruses have emerged as a significant cause of viral gastroenteritis globally. This book contains presentations and discussions by internationally recognized experts on virus structure, replication, pathogenesis, immune response and correlates of protection, molecular–epidemiological surveillance, advances in treatment, and efforts to develop vaccines, particularly against rotavirus disease. The spectrum of viruses covered comprises rotaviruses, human caliciviruses, astroviruses, coronaviruses and viruses causing gut disease in the immunocompromized host. The book not only conveys facts but also gives ample room to lively discussions on many issues at the forefront of research and development.

Spis treści:
Introduction (M. Estes).
Gastroenteritis Viruses: An Overview (R. Glass, et al.).
Structural Studies on Gastroenteritis Viruses (B. Prasad, et al.).
Early Events of Rotavirus Infection: The Search for the Receptor(s) (C. Arias, et al.).
Rotavirus RNA Replication and Gene Expression (J. Patton).
Pathogenesis of Rotavirus Gastroenteritis (M. Estes, et al.).
Correlates of Protection Against Rotavirus Infection and Disease (P. Offit).
Rotavirus Epidemiology and Surveillance (U. Desselberger, et al.).
A Rotavirus Vaccine for Prevention of Severe Diarrhoea of Infants and Young Children: Development, Utilization and Withdrawal (A. Kapikian).
The Molecular Biology of Human Caliciviruses (I. Clarke & P. Lambden).
Molecular Epidemiology of Human Enteric Caliciviruses in The Netherlands (M. Koopmans, et al.).
Molecular Biology of Astroviruses: Selected Highlights (S. Matsui, et al.).
Molecu lar Epidemiology of Human Astroviruses (S. Monroe, et al.).
Enteric Infections with Coronaviruses and Toroviruses (K. Holmes).
Viruses Causing Diarrhoea in AIDS (R. Pollok).
Treatment of Gestrointestinal Viruses (M. Farthing).
Summing–Up (M. Estes).
Index of Contributors.
Subject Index.

Okładka tylna:
Gastroenteritis viruses are a major cause of morbidity and mortality in humans. Many hundreds of thousands of children die annually from rotavirus diarrhoea in the developing world, and although in industrialized countries rotavieus infection is rarely fatal, the economic burden of the disease is substantial. Human caliciviruses have emerged as a significant cause of viral gastroenteritis globally. This book contains presentations and discussions by internationally recognized experts on virus structure, replication, pathogenesis, immune response and correlates of protection, molecular–epidemiological surveillance, advances in treatment, and efforts to develop vaccines, particularly against rotavirus disease. The spectrum of viruses covered comprises rotaviruses, human caliciviruses, astroviruses, coronaviruses and viruses causing gut disease in the immunocompromized host. The book not only conveys facts but also gives ample room to lively discussions on many issues at the forefront of research and development.