The Molecular Basis of Skeletogenesis

This book brings together a cross–fertilization of ideas between human molecular genetics, developmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis. This broad perspective is essential in order to understand the aetiology of genetic diseases affecting skeletal development at all levels from genotype to phenotype, i.e. from mutation to syndrome.
The book encompasses normal and abnormal skeletogenesis process by process, beginning with the signalling pathways that control early patterning events, then the molecular control of osteoblast, chondrocyte and osteoclast differentiation, joint formation and finally osteoclast activity. Each step takes into consideration the results of mouse gene cloning and knockout studies, human molecular genetics, and new mouse studies stimulated by the human information. Such an integrated approach is essential if this new understanding is to be applied for future therapeutic strategies.

Spis treści:
Introduction (B. Hall).
Genetic Control of Skeletal Development (G. Karsentry).
Early Steps in Limb Patterning and Chondrogenesis (S. Pizette & L. Niswander).
General Discussion I.
Developmental Mechanisms of Vertebrate Limb Evolution (M. Cohn).
Regulation of Chondrocyte Growth and Differentiation by Fibroblast Growth Factor Receptor (D. Ornitz).
Defects of Human Skeletogenesis––Models and Mechanisms (S. Mundlos).
Genetic Control of the Cell Proliferation––Differentiation Balance in the Developing Skull Vault: Roles of Fibroblast Growth Factor Receptor Signalling Pathways (G. Morriss–Kay, et al.).
Craniosynostosis and Related Limb Anomalies (A. Wilkie, et al.).
The Parathyroid Hormone–Related Protein and Indian Hedgehog Feedback Loop in the Growth Plate (H. Kronenberg & U. Chung).
Cartilage Matrix Resorption in Skeleto genesis (W. Wu, et al.).
Retinoid signalling and skeletal development (T. Underhill, et al.).
General Discussion II.
Defects in Extracellular Matrix Structural Proteins in the Osteochondrodysplasias (D. Cohn).
Genetic Control of Bone and Joint Formation (D. Kingsley).
The Molecular Basis of Osteoclast Differentiation and Activation (T. Suda, et al.).
Clinical Disorders of Bone Resorption (G. Russell, et al.).
Final Discussion.
Index of Contributors.
Subject Index.

Okładka tylna:
This book brings together a cross–fertilization of ideas between human molecular genetics, developmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis. This broad perspective is essential in order to understand the aetiology of genetic diseases affecting skeletal development at all levels from genotype to phenotype, i.e. from mutation to syndrome.
The book encompasses normal and abnormal skeletogenesis process by process, beginning with the signalling pathways that control early patterning events, then the molecular control of osteoblast, chondrocyte and osteoclast differentiation, joint formation and finally osteoclast activity. Each step takes into consideration the results of mouse gene cloning and knockout studies, human molecular genetics, and new mouse studies stimulated by the human information. Such an integrated approach is essential if this new understanding is to be applied for future therapeutic strategies.