Toxicogenomics: Principles and Applications

With the sequencing of human and other genomes completed, the new field of toxicogenomics is now emerging into the realm of practice. This field brings together many different disciplines to incorporate current genomics knowledge into traditional toxicology. By finding more precise ways to measure the response of living systems and environments to chemical exposures, toxicogenomics promises to greatly alter and improve the drug development process, to name just one area of application.
Toxicogenomics: Principles and Applications provides a unified, thorough text on key breakthrough technologies in genomics, proteomics, metabonomics, and bioinformatics, as well as their applications to toxicology research. Coverage includes: A general introduction to toxicology for nonspecialistsMicroarray/high–density gene expression profilingQuantitative RNA measurementAnalysis of metabolites (metabonomics)Statistics and databases for toxicogenomicsFunctional genomics modelsProtein analysis and profiling
Throughout Toxicogenomics, the emphasis remains on information practitioners can put to use immediately. Numerous illustrations support the text, and a helpful summary lists key software and Internet tools, as well as additional resources. Written for specialists and nonspecialists alike, Toxicogenomics gives a wide range of researchers access to the unique combination of disciplines that characterize this exciting new field.

Spis treści:
Contributors.
Foreword.
Preface.
1. General Toxicology (Ronald C Shank).
2. A Short Introduction to the Expression Profile Toolbox, (Jeffrey F. Waring, et al.).
3. Microarray Manufacture (Emile F Nuwaysir).
4. Scanners (Charles J Tucker).
5. Databases for Toxicogenomics (Pierre R Bushel).
6. Statistics for Toxicogenomics (Thomas J Downey Jr).
7. Real–time and Quantitative PCR (Nigel J Walker and Jeanell e Martinez).
8. Toxicogenomics: Confounding Variables and Data Interpretation (Kevin Morgan, et al.).
9. Introduction ito relationships between toxicology and gene expression (Hisham Hamadeh and Robert Dunn).
10. The Use of a Compendium of Expression Profiles for Mechanism of Toxicity Prediction (Jeffrey F Waring, et al.).
11. Using Genetically–Altered Mice in Toxicogenomics Analysis of Chemical Exposure (J Christopher Corton, et al.).
12. Introduction to High–Throughput Prot ein Expression (Alex Merrick).
13. Analytical Proteomics Approaches To Analysis Of Protein Modifications : Tools For Studying Proteome–Environment Interactions (Daniel Liebler).
14. Introduction to Metabolomics and Metabolic Profiling (Robert London and David Houck).
15. Toxicogenomics Resources (Hisham Hamadeh and Rupesh Amin).
Index.

Nota biograficzna:
Dr. Hisham K. Hamadeh is a research scientist at Amgen. He earned his Ph.D. in toxicology from the University of California at Irvine, following up as a research fellow in the National Center for Toxicogenomics Microarray Center, NIEHS. He has received research excellence awards from the Society of Toxicology and American Cancer Society.
Dr. Cynthia A. Afshari is Associate Director of Toxicology at Amgen. She has served as Director of Basic Research Applications at the Microarray Center and Head of the Gene Regulation Group, Laboratory of Molecular Carcinogenesis, NIEHS. She has also held a position as adjunct professor for the Curriculum in Toxicology at the University of North Carolina, Chapel Hill.

Okładka tylna:
With the sequencing of human and other genomes completed, the new field of toxicogenomics is now emerging into the realm of practice. This field brings together many different disciplines to incorporate current genomics knowledge into traditional toxicology. By finding more precise ways to measure the response o f living systems and environments to chemical exposures, toxicogenomics promises to greatly alter and improve the drug development process, to name just one area of application.
Toxicogenomics: Principles and Applications provides a unified, thorough text on key breakthrough technologies in genomics, proteomics, metabonomics, and bioinformatics, as well as their applications to toxicology research. Coverage includes: A general introduction to toxicology for nonspecialistsMicroarray/high–density gene expression profilingQuantitative RNA measurementAnalysis of metabolites (metabonomics)Statistics and databases for toxicogenomicsFunctional genomics modelsProtein analysis and profiling
Throughout Toxicogenomics, the emphasis remains on information practitioners can put to use immediately. Numerous illustrations support the text, and a helpful summary lists key software and Internet tools, as well as additional resources. Written for specialists and nonspecialists alike, Toxicogenomics gives a wide range of researchers access to the unique combination of disciplines that characterize this exciting new field.