Handbook of Comparative Genomics: Principles and Methodology

Handbook of Comparative Genomics: Principles and Methodology is a practical text for students and researchers covering basic and applied problems in the emerging field of comparative functional genomics. It offers a comparative perspective on the state of the art and key principles of genome sequencing, expression, evolution, and phylogenetics in organelles, prokaryotes, model organisms, and humans. Moreover, the Handbook provides a unique and thorough treatment of biological databases, analysis of the transcriptome and proteome, and the bioinformatic approaches for comparative genome analysis.
The text begins with an introduction to important features of completely sequenced genomes from mitochondria, C. elegans and Arabidopsis to Drosophila and humans. The next section covers cutting–edge analytic approaches involving ESTs, SAGE, DNA microarrays, protein biochips, and 2D gel electrophoresis. The following section deals comprehensively with computational approaches to comparative genome and proteome sequence analysis, including sequence assembly, pattern searching, gene and protein function prediction, and structure prediction. The text concludes with a section discussing genome evolution and molecular phylogenetics. This timely and cutting–edge text also:Presents both the concepts and methodology of comparative genomicsReviews the basic principles of genomics and gene expression analysisCovers the bioinformatics approaches to comparative analysisDiscusses analytic methods in proteomics and transcriptomicsIncludes a comprehensive list of Web resources
The authors draw upon their wealth of teaching and research experience to offer a coherent presentation appropriate for students, trainees, researchers, and scientists across the life sciences.

Spis treści:
SECTION I: GENOME FEATURES.
Preface.
The Prokaryotic Genome.
Eukaryotes.
Organelles.
SECTION II: METHODOLOGIES.
Molecular Biology Techniques for Genomics.
Biological Databases.
Computatonal Methods for the Analysis of Genome Sequence Data.
SECTION III: COMPARATIVE GENOMICS.
Molecular Evolution.
Molecular Phylogeny.
Appendix I.

Nota biograficzna:
Cecilia Saccone is Professor of Molecular Biology at the University of Bari as well as the chair of the National Research Council (CNR) in Bari, Italy.
Graziano Pesole is a professor in the Department of Physiology and General Biochemistry at the University of Milan, Italy.

Okładka tylna:
Handbook of Comparative Genomics: Principles and Methodology is a practical text for students and researchers covering basic and applied problems in the emerging field of comparative functional genomics. It offers a comparative perspective on the state of the art and key principles of genome sequencing, expression, evolution, and phylogenetics in organelles, prokaryotes, model organisms, and humans. Moreover, the Handbook provides a unique and thorough treatment of biological databases, analysis of the transcriptome and proteome, and the bioinformatic approaches for comparative genome analysis.
The text begins with an introduction to important features of completely sequenced genomes from mitochondria, C. elegans and Arabidopsis to Drosophila and humans. The next section covers cutting–edge analytic approaches involving ESTs, SAGE, DNA microarrays, protein biochips, and 2D gel electrophoresis. The following section deals comprehensively with computational approaches to comparative genome and proteome sequence analysis, including sequence assembly, pattern searching, gene and protein function prediction, and structure prediction. The text concludes with a section discussing genome evolution and molecular phylogenetics. This timely and cutting–edge text also:Presents both the concepts and methodology of comparative genomicsReviews the bas ic principles of genomics and gene expression analysisCovers the bioinformatics approaches to comparative analysisDiscusses analytic methods in proteomics and transcriptomicsIncludes a comprehensive list of Web resources
The authors draw upon their wealth of teaching and research experience to offer a coherent presentation appropriate for students, trainees, researchers, and scientists across the life sciences.