Two–Dimensional NMR Spectroscopy: Applications for Chemists and Biochemists

This volume covers the new methodological advances in NMR spectroscopy that have been developed since the publication of the first edition. These include: ′indirect detection′ methods, particularly proton–detected carbon–13 spectra, which have profoundly increased NMR sensitivities; 3– and even higher– dimensional NMR methods which have further increased spectral resolving and correlating power; powerful new computer programs which assist in all phases of data analysis and ultimately make possible rigorous interpretations of complex 2D and higher– dimensional NMR spectra using molecular mechanics and dynamics calculations; and field gradient technology which makes it possible to acquire 2D and higher–dimensional spectra of concentrated samples very rapidly, greatly reducing experiment times. This new edition retains the original format of the first edition with introductory chapters covering descriptions, basic theoretical treatments and experimental aspects of the methods. These are followed by applications chapters representing a broad sampling of important research areas and compound classes

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From the Contents:
Introduction to Multi–Dimensional NMR Methods/
Experimental Aspects of Two–Dimensional NMR/
Proton Detected Heteronuclear and Multi–Dimensional NMR/
Computer–Aided Analysis of Multi–Dimensional NMR Spectra/
NMR of Pesticides/
Protein Structure Calculation Using NMR Restraints/
Studies of Nucleic Acid Structures Based on NMR Results/
Two–Dimensional and Related NMR Methods in Structural Analysis of Oligo– and Polysaccharides/
Steroid Structural Analysis of Two–Dimensional NMR/
Applications of Two–Dimensional NMR to the Characterization of Synthetic Organic Materials/
Two–Dimensional NMR in Natural Products and Pharmaceutical Chemistry