Psychobiological Approaches for Anxiety Disorders: Treatment Combination Strategies

Traditional anti–anxiety medications and cognitive behavioral therapy (CBT) are popular treatments for clients suffering from a wide range of anxiety disorders. However, there is a clear need for improved efficacy of these approaches, either when administered as mono–therapies or in combination. A promising contemporary approach to combination therapy is to enhance the mechanism of CBT utilizing pharmacological agents. Psychobiological Approaches for Anxiety Disorders represents the first work to offer a comprehensive overview of the latest empirical evidence and research results on conventional and novel combination therapies for the treatment of anxiety disorders. Leading experts in neuroscience, psychiatry, psychopharmacology, emotion research, and psychotherapy address the evidence for and against combining pharmacological agents with CBT for the treatment of anxiety disorders, and outline the most promising future approaches. The result is an invaluable resource for clinicians and researchers alike.  

About the Contributors  vii About the Editor xi Introduction  1 Stefan G. Hofmann Chapter 1 The Biology and Efficacy of Combination Strategies for Anxiety Disorders  5 Keith A. Ganasen and Dan J. Stein Chapter 2 Benzodiazepines  25 Bridget A. Hearon and Michael W. Otto Chapter 3 Tricyclic Antidepressants and Monoamine Oxidase Inhibitors  41 Franklin R. Schneier Chapter 4 Selective Serotonin Reuptake Inhibitors, Reversible Inhibitors of Monoamine Oxidase–A, and Buspirone  61 Borwin Bandelow, Markus Reitt, and Dirk Wedekind Chapter 5 D–Cycloserine 75 Adam J. Guastella and Gail A. Alvares Chapter 6 Yohimbine Hydrochloride  91 Samantha G. Farris, Michelle L. Davis, Lindsey B. DeBoer, Jasper A. J. Smits, and Mark B. Powers Chapter 7 Cortisol 109 Leila Maria Soravia and Dominique J.–F. de Quervain Chapter 8 Oxytocin 123 Markus Heinrichs, Frances S. Chen, and Gregor Domes Chapter 9 Dietary Supplements 145 Lindsey B. DeBoer, Michelle L. Davis, Mark B. Powers, and Jasper A. J. Smits Chapter 10 A Roadmap for the Research and Practice of Combination Strategies 181 Stefan G. Hofmann Index 195

Stefan G. Hofmann is Professor of Psychology at Boston University and the Director of the Psychotherapy and Emotion Research Laboratory. The incoming President of the Association for Behavioral and Cognitive Therapies, he is widely published with more than 200 peer–reviewed journal articles and book chapters, and 10 books, including An Introduction to Modern CBT (2011, Wiley–Blackwell) .