Biology and Diseases of the Ferret

Biology and Diseases of the Ferret, Third Edition has been thoroughly revised and updated to provide a current, comprehensive reference on the ferret. Encyclopedic in scope, it is the only book to focus on the characteristics that make the ferret an important research animal, with detailed information on conditions, procedures, and treatments. Offering basic information on biology, husbandry, clinical medicine, and surgery, as well as unique information on the use of ferrets in biomedical research, Biology and Diseases of the Ferret is an essential resource for investigators using ferrets in the laboratory and for companion animal and comparative medicine veterinarians.  The Third Edition adds ten completely new chapters, covering regulatory considerations, black–footed ferret recovery, diseases of the cardiovascular system, viral respiratory disease research, morbillivirus research, genetic engineering, hearing and auditory function, vision and neuroplasticity research, nausea and vomiting research, and lung carcinogenesis research.  Additionally, the anesthesia, surgery, and biomethodology chapter has been subdivided into three and thoroughly expanded. The book also highlights the ferret genome project, along with the emerging technology of genetically engineered ferrets, which is of particular importance to the future of the ferret as an animal model in research and will allow the investigation of diseases and their genetic basis in a small, easily maintained, non–rodent species.  Key features   Offers a revised edition of the only book available covering the use of ferrets in biomedical research Includes new chapters on regulatory considerations, black–footed ferret recovery, physical examination and diagnosis, diseases of the cardiovascular system, bacterial and mycoplasmal diseases, viral respiratory disease research, morbillivirus research, genetic engineering, hearing and auditory function, vision and neuroplasticity research, nausea and vomiting research, and lung carcinogenesis research Expands the existing information on anesthesia and surgery, viral disease research, and neuroscience research to provide a wealth of new information Provides detailed information on conditions, procedures, and treatments relevant to this important species Thoroughly revised and updated to provide a current reference that is exhaustive in scope Published in association with the American College of Laboratory Animal Medicine

Contributors Preface Section I Biology and Husbandry 3 Chapter 1 Taxonomy, History, and Use James G. Fox Chapter 2 Anatomy of the Ferret Howard Evans and Nguyen Quoc An Chapter 3 Neuroanatomy of the Ferret Brain with Focus on the Cerebral Cortex Christopher D. Kroenke, Brian D. Mills, Jaime F. Olavarria, and Jeffrey J. Neil Chapter 4 Physiology of the Ferret Mark T. Whary Chapter 5 Nutrition of the Ferret James G. Fox, Carrie S. Schultz, and Brittany M. Vester Boler Chapter 6 Housing and Management James G. Fox and Rosemary Broome Chapter 7 Normal Clinical and Biological Parameters James G. Fox Chapter 8 Growth and Reproduction James G. Fox, Judi A. Bell, and Rosemary Broome Chapter 9 Regulatory Considerations Robert P. Marini Chapter 10 Recovery of the Black–Footed Ferret Rachel Santymire, Heather Branvold–Faber, and Paul Marinari Section II Diseases and Clinical Applications Chapter 11 Physical Examination, Preventive Medicine, and Diagnosis in the Ferret Robert P. Marini Chapter 12 Anesthesia Jeffrey C. Ko and Robert P. Marini Chapter 13 Surgery Stephen J. Mehler Chapter 14 Diseases of the Hematopoietic System Jöerg Mayer, Susan E. Erdman, and James G. Fox Chapter 15 Diseases of the Genitourinary System James G. Fox and Judith A. Bell Chapter 16 Diseases of the Gastrointestinal System Kirk J. Maurer and James G. Fox Chapter 17 Diseases of the Endocrine System Cassandra L. Miller, Robert P. Marini, and James G. Fox Chapter 18 Diseases of the Cardiovascular System Robert A. Wagner Chapter 19 Other Systemic Diseases James G. Fox Chapter 20 Viral Diseases of Ferrets Matti Kiupel and David Perpiñan Chapter 21 Bacterial and Mycoplasmal Diseases Alton G. Swennes and James G. Fox Chapter 22 Parasitic Diseases Mary Patterson, James G. Fox, and Mark L. Eberhard Chapter 23 Mycotic Diseases James G. Fox Chapter 24 Neoplastic Diseases James G. Fox, Sureshkumar Muthupalani, Matti Kiupel, and Bruce Williams Section III Research and Applications Chapter 25 The Ferret in Viral Respiratory Disease Research Deborah R. Taylor Chapter 26 The Ferret in Morbillivirus Research Veronika von Messling Chapter 27 Use of the Ferret in Cardiovascular Research James P. Morgan Chapter 28 Genetic Engineering in the Ferret Xingshen Sun, Ziying Yan, Xiaoming Liu, Alicia K. Olivier, and John F. Engelhardt Chapter 29 Hearing and Auditory Function in Ferrets Fernando R. Nodal and Andrew J. King Chapter 30 The Ferret as a Model for Visual System Development and Plasticity Jitendra Sharma and Mriganka Sur Chapter 31 The Ferret in Nausea and Vomiting Research: Lessons in Translation of Basic Science to the Clinic Nathalie Percie du Sert and Paul L.R. Andrews Chapter 32 The Ferret in Lung Carcinogenesis and Nutritional Chemoprevention Research Xiang–Dong Wang and Chun Liu Index

James G. Fox , DVM, MS, DACLAM, is Professor and Director at MIT’s Division of Comparative Medicine, as well as Chair of ACLAM’s publications committee.  He is also an Adjunct Professor at Tufts University’s Cummings School of Veterinary Medicine and at the University of Pennsylvania’s School of Veterinary Medicine. Robert P. Marini , DVM, DACLAM, is Assistant Director and Chief of Veterinary Surgical Resources at MIT’s Division of Comparative Medicine and Lecturer in Health, Science and Technology, also at MIT.