Insulin Resistance: Insulin Action and its Disturbances in Disease

Insulin resistance is a key abnormality associated with a number of common metabolic and cardiovascular diseases, including type 2 diabetes and obesity. This has therefore been an area of intense scrutiny for researchers worldwide. Over the last decade in particular, a plethora of defining studies have helped to cast light on both the clinical and the molecular aspects of insulin resistance. First, study of rare syndromes of severe insulin resistance has led to better definition of these conditions and, in many cases, to a better understanding of the molecular basis of these diseases. Second, the importance of insulin resistance to the development and progression of common diseases such as type 2 diabetes, polycystic ovarian syndrome, cardiovascular disease and obesity is better appreciated. Third, we now have drugs that can reduce insulin resistance significantly and this has had an impact on both basic and clinical research in the field. Consequently, we are beginning to see a major paradigm shift in how type 2 diabetes and the metabolic syndrome are being managed, with a greater emphasis on addressing insulin resistance than ever before.
In this book, several leading investigators who have made seminal contributions to the field have written chapters covering the normal biology of insulin action, the pathophysiology of insulin resistance, the myriad clinical consequences of insulin resistance, and finally, current and future prospects for its treatment. The book therefore not only provides an up–to–date perspective of the subject from several of the leading thinkers in the field, but should also serve as a useful source of reference for students, researchers and clinicians.

Spis treści:
Preface.
List of Contributors
1. The Insulin Receptor and Downstream Signalling (Ken Siddle).
2. Insulin–Mediated Regulation of Glucose Metabolism (Daniel Konrad, Assaf Rudich and Amira Klip).
3. Insulin Action on Lipid Metabolism (Keith N. Frayn and Fredrik Karpe).
4. The Effect of Insulin on Protein Metabolism (Laura J. S. Greenlund and K. Sreekumaran Nair).
5. Genetically Modified Mouse Models of Insulin Resistance (Gema Medina, Christopher Lelliott and Antonio J. Vidal–Puig).
6. Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes (Henning Beck–Nielsen, Frank Alford and Ole Hother–Nielsen).
7. Central Regulation of Peripheral Glucose Metabolism (Stanley M. Hileman and Christian Bjørbæk).
8. Relationship Between Fat Distribution and Insulin Resistance (Philip G. McTernan, Aresh Anwar and Sudhesh Kumar).
9. PPARy and Glucose Homeostasis (Robert K. Semple and Stephen O’Rahilly).
10. Adipokines and Insulin Resistance (Daniel K. Clarke and Vidya Mohamed–Ali).
11. Dietary Factors and Insulin Resistance (Jeremy Krebs and Susan Jebb).
12. Physical Activity and Insulin Resistance (Nicholas J. Wareham, Søren Brage, Paul W. Franks and Rebecca Abbott).
13. Genetics of the Metabolic Syndrome (George Argyropoulos, Steven Smith and Claude Bouchard).
14. Insulin Resistance and Dyslipidaemia (Benoît Lamarche and Jean–François Mauger).
15. Insulin Resistance, Hypertension and Endothelial Dysfunction (Stephen J. Cleland and John M. C. Connell).
16. Insulin Resistance and Polycystic Ovary Syndrome (Neus Potau).
17. Syndromes of Severe Insulin Resistance (SSIRs) (David Savage and Stephen O’Rahilly).
18. Therapeutic Strategies for Insulin Resistance (Harpal S. Randeva, Margaret Clarke and Sudhesh Kumar).
19. Drug Therapy for Insulin Resistance – a Look at the Future (Bei B. Zhang and David E. Moller).
Index.

Okładka tylna:
Insulin resistance is a key abnormality associated with a number of common metabolic and cardiovascular diseases, including type 2 diabetes and obesity. This has therefore been an area of intense scrutiny for researchers worldwide. Over the last decade in particular, a plethora of defining studies have helped to cast light on both the clinical and the molecular aspects of insulin resistance. First, study of rare syndromes of severe insulin resistance has led to better definition of these conditions and, in many cases, to a better understanding of the molecular basis of these diseases. Second, the importance of insulin resistance to the development and progression of common diseases such as type 2 diabetes, polycystic ovarian syndrome, cardiovascular disease and obesity is better appreciated. Third, we now have drugs that can reduce insulin resistance significantly and this has had an impact on both basic and clinical research in the field. Consequently, we are beginning to see a major paradigm shift in how type 2 diabetes and the metabolic syndrome are being managed, with a greater emphasis on addressing insulin resistance than ever before.
In this book, several leading investigators who have made seminal contributions to the field have written chapters covering the normal biology of insulin action, the pathophysiology of insulin resistance, the myriad clinical consequences of insulin resistance, and finally, current and future prospects for its treatment. The book therefore not only provides an up–to–date perspective of the subject from several of the leading thinkers in the field, but should also serve as a useful source of reference for students, researchers and clinicians.