Drug Resistance in Epilepsy: Lessons from Oncology

Drug resistance in epilepsy is an important clinical problem. About 20% of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.

Spis treści:
Chair′s Introduction (V. Ling).
The problem of the drug–resistant epilepsies (J. W. Sander).
Drug resistance molecules: lessons from oncology (George L. Scheffer and Rik J. Scheper).
Drug resistance in epilepsy: the role of the blood–brain barrier (N. Joan Abbott, et al.).
P glycoprotein and the mechanism of multidrug resistance (A. Varadi, et al).
Drug resistance caused by multidrug resistance–associated proteins (J. Wijnholds).
Reversal of multidrug resistance: lessons from clinical oncology (S. E. Bates, et al.).
Clinical development of P glycoprotein modulators in oncology (A. Oza).
Gene expression profiling of epothilone A–resistant cells (P. Atadja, et al.).
Imaging of P glycoprotein function in vivo with PET (N. H. Hendrikse and W. Vaalburg).
Animal models of drug–resistant epilepsy (W. Loscher).
Drug resistance in epilepsy: h uman epilepsy (S. M. Sisodiya, et al).
Cellular mechanisms of pharmacoresistance in slices from epilepsy surgery (R. A. Deisz).
Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo (U. Brinkmann).
OC144–093, a novel P glycoprotein inhibitor for the enhancement of anti–epileptic therapy (M. J. Newman, et al.).
Closing remarks (V. Ling).
Index of contributors.
Subject Index.

Okładka tylna:
Drug resistance in epilepsy is an important clinical problem. About 20% of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.