Cardiotoxicity of Non–Cardiovascular Drugs

Some drugs which are not aimed at treating heart diseases have nevertheless been found to have profound effects on the cardiovascular system. Cardiotoxicity is one of the major untoward effects of drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. In recent years a number of non–cardiac blockbuster drugs have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been halted prior to marketing or required labelling changes that significantly restricted their use.
In Cardiotoxicity of Non–Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read–outs of cardiac events induced by a broad variety of noncardiovascular drugs. Emphasis is also paid to the preclinical screening of drug cardiotoxicity.
Topics include:
metabolic targets of cardiotoxicityregulatory aspectscellular mechanisms, molecular targets and structure–activity relationships in arrhythmias by antihistamines, psychoactive drugs and antimicrobial agentscardiovascular toxicity of antitumor drugscardiovascular toxicities of non–steroidal anti–inflammatory drugscardiovascular toxicities of antiretroviral therapies
Cardiotoxicity of Non–Cardiovascular Drugs is an essential guide to this important area of drug development and surveillance. It will find a place on the bookshelves of basic and clinical researchers, regulators, and students interested in oncology, cardiology, pharmacology, medicinal chemistry and drug development.


Spis treści:
List of Contributors
1. Mitochondrial Dysfunction In Cell Injury and Cardiotoxicity
Fabio Di Lisa, Martina Semenzato, Andrea Carpi, Sara Menazza, Nina Kaludercic, Roberta Menabò, Marcella Canton
2. Cardiovascular Liabilities of Drugs: Regulatory Aspects
Claudio Arrigoni< br>3. Cellular Mechanisms, Molecular Targets, and Structure–Function Relationships In Drug–Induced Arrhythmias: The Case Of Antihistamines, Psychoactive Drugs, and Antimicrobial Agents
Maria Virginia Soldovieri and Maurizio Taglialatela
4. Cardiovascular Toxicity of Antitumor Drugs: Dimensions of the Problem in Children
Rebecca Scully, Louis Pruitt, Steven E. Lipshultz
5. Cardiovascular Toxicity of Antitumor Drugs: Dimension of the Problem in Adult Settings
Joseph R. Carver and Chaitali J. Desai
6. Diagnostic Aspects of Cardiovascular Toxicity of Antitumor Drugs
Michael S. Ewer, Thomas M. Suter
7. Cardiovascular Toxicity of Antitumor Drugs: Translating Molecular Mechanisms into Clinical Facts
Pierantonio Menna, Emanuela Salvatorelli, Carlo Salsano, Luca Gianni∗, and Giorgio Minotti
8. NSAID Action and the Foundations for Cardiovascular Toxicity
Anna L. Blobaum and Lawrence J. Marnett
9. Cardiovascular toxicities of NSAIDS: Epidemiologic aspects
Antonio González–Pérez, Luis Alberto García Rodriguez
10. Cardiovascular Toxicities of Life–Saving Drugs: Antiviral Therapy
James J. Kohler &amp; William Lewis


Okładka tylna:
Some drugs which are not aimed at treating heart diseases have nevertheless been found to have profound effects on the cardiovascular system. Cardiotoxicity is one of the major untoward effects of drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. In recent years a number of non–cardiac blockbuster drugs have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been halted prior to marketing or required labelling changes that significantly restricted their use.
In Cardiotoxicity of Non–Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read–outs of cardiac events induced by a broad variety of noncardiovascular drugs. Emphasis is also paid to the preclinical screening of drug cardiotoxicity.
Topics include:
metabolic targets of cardiotoxicityregulatory aspectscellular mechanisms, molecular targets and structure–activity relationships in arrhythmias by antihistamines, psychoactive drugs and antimicrobial agentscardiovascular toxicity of antitumor drugscardiovascular toxicities of non–steroidal anti–inflammatory drugscardiovascular toxicities of antiretroviral therapies
Cardiotoxicity of Non–Cardiovascular Drugs is an essential guide to this important area of drug development and surveillance. It will find a place on the bookshelves of basic and clinical researchers, regulators, and students interested in oncology, cardiology, pharmacology, medicinal chemistry and drug development.