The Pulmonary Endothelium: Function in Health and Disease

The pulmonary endothelium interacts with both blood and underlying vascular smooth muscle.
As well as being critical for gas exchange, the lung endothelium is now implicated in the modulation
of a variety of processes, such as inflammation, thrombosis, vasoconstriction, and vascular permeability. Our understanding of the pulmonary endothelium has increased enormously in recent years, particularly its role in several diseases, including pulmonary hypertension, emphysema, acute respiratory distress syndrome, and cancer.
Research in many fields continues to elucidate how the pulmonary endothelium contributes to the etiology and pathophysiology of lung disease and to identify possible therapeutic strategies. This book clearly presents the current body of knowledge and explores how this knowledge may be applied to increase our understanding of disease and develop new types of treatment. Above all, it aims to improve the outcomes of acute and chronic lung diseases.
The book is divided into three sections. The first describes the normal pulmonary endothelium, including development, structure, cell biology, signalling, function, heterogeneity, interactions with circulating cells and mesenchymal cells, and the endothelium of the bronchial circulation. The second section deals with mechanisms and consequences of pulmonary endothelial cell injury, ranging from effects on endothelial cells to organ injury, including protection against lung permeability and drug targeting to pulmonary endothelium. The third section focuses on the pulmonary endothelium in disease.
Describes and discusses the lung endothelium as the first and principal locus of blood–born information processing
Reviews maintenance of normal lung vascular tone and modulation of vasoconstriction
Discusses the lung endothelium in modulation of pulmonary vascular remodelling
Highlights recent work on the important role of the lung endothelium in the pathogenesis of lung diseases
Th e Pulmonary Endothelium provides specialist physicians and clinical researchers in pulmonology,
critical care, and allergy with the most up to date information on core physiological processes in lung
disease, and offers insights into current and future approaches to management.


Spis treści:
List of Contributors
Introduction, Sharon Rounds and Norbert Voelkel
SECTION I: NORMAL PULMONARY ENDOTHELIUM. STRUCTURE, FUNCTION, CELL BIOLOGY
1: Development of the Pulmonary Endothelium in Development of the Pulmonary
Circulation: Vasculogenesis and Angiogenesis, Margaret A. Schwarz and Ondine B. Cleaver
2: Anatomy of the Pulmonary Endothelium, Radu V. Stan
3: Cadherins and Connexins in Pulmonary Endothelial Function, Kaushik Parthasarathi
and Sadiqa K. Quadri
4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix,
Katie L. Grinnell and Elizabeth O. Harrington
5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular
Barrier Function, Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta
6: Pulmonary Endothelium and Nitric Oxide, Yunchao Su and Edward R. Block
7: Pulmonary Endothelial Cell Surface Metabolic Functions, Usamah S. Kayyali and
Barry L. Fanburg
8: Cell Biology of Lung Endothelial Permeability, Guochang Hu and Richard D. Minshall
9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study
of Calcium Channels, Donna L. Cioffi, Songwei Wu and Troy Stevens
10: Pulmonary Endothelial Interactions with Leukocytes and Platelets, Rosana Souza
Rodrigues and Guy A. Zimmerman
11: Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory,
and Fibrotic Responses in the Pulmonary Circulation, Kurt R. Stenmark, Evgenia V.
Gerasimovskaya, Neil Davie and Maria Frid
12: Pulmo nary Endothelium and Vasomotor Control, Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta
13: Pulmonary Endothelial Progenitor Cells, Bernard Thébaud and Mervin C. Yoder
14: Bronchial Vasculature: The Other Pulmonary Circulation, Elizabeth Wagner
15: Mapping Protein Expression on Pulmonary Vascular Endothelium,
Kerri A. Massey and Jan E. Schnitzer
SECTION II: MECHANISMS AND CONSEQUENCES OF PULMONARY ENDOTHELIAL CELL
INJURY
16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis,
Qing Lu and Sharon Rounds
17: Oxidant–Mediated Signaling and Injury in Pulmonary Endothelium, Kenneth E.
Chapman, Shampa Chatterjee and Aron B. Fisher
18: Hypoxia and the Pulmonary Endothelium, Matthew Jankowich, Gaurav Choudhary, and Sharon Rounds
19: Viral Infection and Pulmonary Endothelial Cells, Norbert F. Voelkel
20: Effects of Pressure and Flow on the Pulmonary Endothelium, Wolfgang M. Kuebler
21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability,
Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia
22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium, Vladimir R.
Muzykantov
SECTION III: PULMONARY ENDOTHELIUM IN DISEASE
23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn,
Yuansheng Gao and J. Usha Raj
24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung,
Sumegha Mitra, Daniel Turner Lloveras, Shwu–Fan Ma and Joe G. N. Garcia
25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets:
Implications for Disease Pathogenesis, Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel
26: Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease,
Norbert F. Voelkel and Ramesh Natarajan
27: Pulmonary Endothelium and Pulmonary Hypertension, Rubin M. Tuder and Serpil C.
Erzurum
28: Collagen Vascular Diseases and Pulmonary Endothelium, Pradeep R. Rai and
Carlyne D. Cool
29: Pulmonary Endothelium in Thromboembolism, Irene M. Lang
30: Pulmonary Endothelium and Malignancies, Abu–Bakr Al–Mehdi
Epilogue, Norbert F. Voelkel
Index


Okładka tylna:
The pulmonary endothelium interacts with both blood and underlying vascular smooth muscle.
As well as being critical for gas exchange, the lung endothelium is now implicated in the modulation
of a variety of processes, such as inflammation, thrombosis, vasoconstriction, and vascular permeability. Our understanding of the pulmonary endothelium has increased enormously in recent years, particularly its role in several diseases, including pulmonary hypertension, emphysema, acute respiratory distress syndrome, and cancer.
Research in many fields continues to elucidate how the pulmonary endothelium contributes to the etiology and pathophysiology of lung disease and to identify possible therapeutic strategies. This book clearly presents the current body of knowledge and explores how this knowledge may be applied to increase our understanding of disease and develop new types of treatment. Above all, it aims to improve the outcomes of acute and chronic lung diseases.
The book is divided into three sections. The first describes the normal pulmonary endothelium, including development, structure, cell biology, signalling, function, heterogeneity, interactions with circulating cells and mesenchymal cells, and the endothelium of the bronchial circulation. The second section deals with mechanisms and consequences of pulmonary endothelial cell injury, ranging from effects on endothelial cells to organ injury, including protection against lung permeability and drug targeting to pulmonary endotheli