General and Applied Toxicology: 6 Volume Set

Encompassing 150 articles written by leading scientists in the field, the third edition of General and Applied Toxicology provides a comprehensive and in–depth review of the basic science of toxicology, its specializations, and the application of toxicological knowledge.
This new edition reflects developments within the field that have taken place since the second edition was published in 1999.  These include:  New information developed in the areas of both the fundamental and applied aspects of toxicologyConsiderable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scopeChanging approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology
General and Applied Toxicology, 3rd Edition is the first port of call for academic researchers, industrial researchers, regulatory professionals, and advanced students looking for timely and authoritative information in the field. Due to the increase in public and media interest in exposure to toxic substances, this provides an indispensable general reference source for general physicians, lawyers, law enforcement agencies, information resource facilities, and members of the general public.

Spis treści:
Preface to Third Edition.
Preface to Second Edition.
Preface to First Edition.
List of Contributors.
Frequently used Abbreviations xxx.
PART ONE: BASIC SCIENCE.
1 Basic Elements of Toxicology (Bryan Ballantyne, Timothy C. Marrs and Tore Syversen).
2 Acute Toxicity (David J. Andrew).
3 Repeated Exposure Toxicity (Bryan Ballantyne).
4 Biotransformation of Xenobiotics (John A. Timbrell and Timothy C. Marrs).
5 Toxicokinetics of Xenobiotic and Metabolite Dis tribution and Excretion (Mario A. Inchiosa, Jr. and Mario E. Inchiosa).
6 Toxicokinetics (Ashley Roberts and Andrew G. Renwick).
7 Physiologically Based Pharmacokinetic Modelling (Hon–Wing Leung).
8 Toxicology of Chemical Mixtures (Kannan Krishnan and Jonathan Boyd).
9 Evaluation of Toxicological Interactions for the Dose–Response Assessment of Chemical Mixtures (Kannan Krishnan, Sastry Isukapalli and Jonathan Boyd).
PART TWO: MOLECULAR AND CELLULAR ASPECTS OF TOXICOLOGY.
10 Molecular and Cellular Concepts in Toxicology (Michael A. Lynes).
11 Cell Death and Apoptosis (Sidhartha D. Ray and George B. Corcoran).
12 Introduction to Mitochondrial Toxicity (Yvonne Will and James A. Dykens).
13 Toxicity of Peroxisome Proliferators (John P. Vanden Heuvel).
14 Cellular Tight Junctions as Mediators of Adverse Effects (Yula Sambuy).
15 Reactive Oxygen Species in the Induction of Toxicity (Giorgio Lenaz and Paola Strocchi).
16 Glutathione and Glutathione–S–Transferase in Detoxification Mechanisms (Xianchun Li).
17 Nitric Oxide Pathways in Toxic Responses (Jeffrey D. Laskin, Diane E. Heck and Debra L. Laskin).
18 A Metabolomic Perspective of Small Molecule Toxicity (Andrew D. Patterson and Jeffrey R. Idle).
19 Xenobiotic–Induced Inflammation: Pathogenesis and Mediators (Peter J. M. Clements).
20 Chemokines as Mediators of Toxicant–Induced Inflammation and Fibrosis (Francois Huaux, Sandra Lo Re and Dominique Lison).
21 Toxicogenomics and the Evolution of Systems Toxicology (Michael D. Waters and B. Alex Merrick).
22 Endocrine Disruption in Toxic Responses (Shigeyuki Kitamura, Kazumi Sugihara, Kazuo Nakamura, Yaichiro Kotake, Akihiko Kashiwagi and Nariaki Fujimoto).
PART THREE: FACTORS INFLUENCING TOXICOLOGY.
23 Environmental and Endogenous Factors Determining the Expression of Toxicity (Karen E. Stine).
24 Chronotoxicology (Karam F. Soliman and Elizabeth A. Mazzio).
25 Effects of Chirality on Toxicity (Mae Grace Nilos, Jay Gan and Daniel Schlenk).
26 The Influence of Temperature on Toxicity (Christopher J. Gordon and Pamela J. Rowsey).
27 Development of Tolerance to the Toxicity of Xenobiotics (Frode Fonnum).
PART FOUR: METHODOLOGY.
28 Statistics for Toxicology (Peter N. Lee and David Lovell).
29 Pathological Techniques in Toxicology (Peter Greaves).
30 Clinical Chemistry in Toxicity Testing: Scope and Methods (Sylvie Gosselin, Lila Ramaiah and Lesley Earl).
31 Haematology and Toxicology (Timothy C. Marrs and Simon Warren).
32 Imaging Techniques in Neurotoxicology Research and Development (Philippe Hantson and Thierry Duprez).
33 Alternatives to In vivo Studies in Toxicology (Shayne C. Gad).
34 Antidotal Studies (D. Nicholas Bateman and Timothy C. Marrs).
35 Toxicity Data Obtained From Human Studies (Martin F. Wilks and Hugo Kupferschmidt).
36 Significance of Biochemical Markers in Applied Toxicology (Fernando Gil and Antonio F. Hernández).
37 Oncology Biomarkers (Michael A. Tainsky).
38 Quality Assurance in Toxicology Studies (J. Rodney Pateman).
39 Animal Welfare in the Toxicology Laboratory (Roy C. Myers and Bennett J. Varsho).
40 Chemical and Biological Occupational Hazards in the Toxicology Laboratory (Bryan Ballantyne).
41 Information Resources for Toxicology (Philip Thomas Copestake).
PART FIVE: TOXICITY BY ROUTES.
42 Toxicities Associated with Parenteral Nutrition (Judy L. Aschner and Heather M. Furlong).
43 Peroral Toxicity (William J. Brock).
44 Cutaneous Toxicology (Jim E. Riviere and Nancy A. Monteiro–Riviere).
45 Inhalation Toxicity (Geoff H. Pi gott).
46 Mixed Routes of Exposure (John J. Clary).
PART SIX: TARGET ORGAN AND TISSUE TOXICITY.
47 Neurotoxicology (Frode Fonnum).
48 The Role of Behavioural Toxicity in Risk Assessment (Bernard Weiss).
49 Peripheral Chemosensory Irritation: Fundamentals, Investigation and Applied Considerations (Bryan Ballantyne).
50 Responses of the Kidney to Toxic Compounds (Edward A. Lock).
51 Allergic Asthma and Rhinitis: Toxicological Considerations (Jean F. Regal).
52 Laboratory Recognition of Potential Xenobiotic Respiratory Sensitizers (Marsha D.W. Ward and Cherie Pucheu–Haston).
53 Ophthalmic Toxicology (Bryan Ballantyne).
54 Cutaneous Toxicology (Steven J. Hermansky).
55 Photoallergy (Ruta Dubakiene).
56 Ototoxicity (Andrew Forge, Ruth Taylor and Ernest S. Harpur).
57 Cardiac Toxicology (Lalita A. Bharadwaj).
58 Cardiac Toxicity of Anthracyclines (Richard D. Olson and Barry J. Cusack).
59 Hepatotoxicity (Richard H. Hinton, Paul Grasso and Timothy C. Marrs).
60 Toxicology of the Exocrine Pancreas (John R. Foster).
61 Skeletal Muscle Toxicology (M. Alexander Kenaston, Ellen A. Abramson, Matthew E. Pfeiffer and Edward M. Mills).
62 Cartilage and Bone as Target Tissues for Toxic Materials (Alan B.G. Lansdown).
63 Toxicology of the Endocrine System (Robert W. Kapp Jr. and John A. Thomas).
64 Immunotoxicology (Robert W. Luebke, Celine A. Beamer, Christal Bowman, Jamie DeWitt, Kymberly Gowdy, Victor J. Johnson, David M. Shepherd and Dori M. Ger).
65 Phototoxicology (J. Frank Nash).
PART SEVEN: GENETIC TOXICOLOGY, ONCOGENESIS, DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY.
66 Mutagenesis (Anthony Lynch).
67 Cytogenetics (Diana Anderson, Adolf Baumgartner and Eduardo Cemeli).
68 Genetic Toxicology Testing and its Relevance to Human Ris