Functionalised N–Heterocyclic Carbene Complexes

N–heterocyclic carbenes (NHCs) have found increasing use as reagents for a range of organic transformations and in asymmetric organocatalysis. The performance of these molecules can be improved and tuned by functionalisation. Functionalised carbenes can anchor free carbenes to the metal site, introduce hemilability, provide a means to immobilise transition metal carbene catalysts, introduce chirality, provide a chelate ligand or bridge two metal centres. NHCs can be attached to carbohydrates and campher, derived from amino acids and purines, and they can be used as organocatalysts mimicking vitamin B1 or as weak “solvent” donors in lanthanide chemistry.
Functionalised N–Heterocyclic Carbene Complexes describes major trends in functionalised NHC ligands, aiming to assist readers in their attempts to develop and apply their own functionalised carbenes. After an introduction to the chemistry and behaviour of NHC, the book gives a detailed description of functionalised carbenes and their complexes according to a range of functional groups, each with a discussion of the synthetic route, structure, stability and performance.
Functionalised N–Heterocyclic Carbene Complexes is an essential guide to fine–tuning this important class of compounds for practitioners, researchers and advanced students working in synthetic organometallic and organic chemistry and catalysis.


Spis treści:
Abbreviations
Introduction
Chapter 1: The Nature of N–Heterocyclic Carbenes
1.1 Synthesis
1.2 Properties of NHC
References
Chapter 2: Why Functionalisation
2.1 Phosphane Mimick
2.2 Hemilability
2.3 Chirality
2.4 Ligand Geometry
2.5 Catalysis
References
Chapter 3: NHC with Neutral Tethers
3.1 Amine Functionalities
3.2 Oxygen containing groups
3.3 Phosphane functionalities
3.4 Bis–carbene ligands
3.5 Tris–N –Heterocyclic carbene ligands
3.6 Pincer carbenes
References
Chapter 4: NHC with Anionic Functional Groups
4.1 Oxygen containing groups
4.2 Nitrogen containing groups.
4.3 NHC ligands incorporating cyclopentadienide Cp moieties.
4.4 Transition metal NHC complexes involved in the activation of C–H bonds.
4.5 Immobilisation of the Catalyst
4.6 Sulphur containing functional groups
References
Chapter 5: Chiral N–Heterocyclic Carbenes
References
Chapter 6: Natural Products
6.1 Thiazole
6.2 Amino Acids
6.3 Purines and Xanthines
6.4 Carbohydrates
6.5 Miscellaneous
References
Index


Okładka tylna:
N–heterocyclic carbenes (NHCs) have found increasing use as reagents for a range of organic transformations and in asymmetric organocatalysis. The performance of these molecules can be improved and tuned by functionalisation. Functionalised carbenes can anchor free carbenes to the metal site, introduce hemilability, provide a means to immobilise transition metal carbene catalysts, introduce chirality, provide a chelate ligand or bridge two metal centres. NHCs can be attached to carbohydrates and campher, derived from amino acids and purines, and they can be used as organocatalysts mimicking vitamin B1 or as weak “solvent” donors in lanthanide chemistry.
Functionalised N–Heterocyclic Carbene Complexes describes major trends in functionalised NHC ligands, aiming to assist readers in their attempts to develop and apply their own functionalised carbenes. After an introduction to the chemistry and behaviour of NHC, the book gives a detailed description of functionalised carbenes and their complexes according to a range of functional groups, each with a discussion of the synthetic route, structure, stability and performance.
Functionalised N–Heterocyclic Carbene Complexes is an essential guide to fine– tuning this important class of compounds for practitioners, researchers and advanced students working in synthetic organometallic and organic chemistry and catalysis.