Lecture Notes: Haematology

Haematology Lecture Notes is an accessible and concise best–selling study guide, outlining the physiology, pathology and treatment of the most common blood disorders. Extensively revised and updated to reflect the considerable advances in the understanding of the molecular biology and pathogenesis of haematological disorders, it provides the core knowledge required by all medical students and junior doctors.

Key features include:

New material on coagulation and transfusion Expanded coverage of haematopoiesis A complete update of all malignant haematology content

A brand new companion website at www.lecturenoteseries.com/haematology featuring interactive MCQs with feedback on each answer selected, chapter summaries and revision notes in PowerPoint and PDF formats, and all the figures from the book in PowerPoint format

Whether approaching haematology for the first time, or looking for a refresher, Haematology Lecture Notes will enable students and junior doctors to develop an understanding of both the basic science and clinical aspects of this specialty.

Preface to the first edition vi

Preface to the ninth edition vii

1 An introduction to haematopoiesis, 1

2 Anaemia: General principles, 10

3 Haemolytic anaemias, 26

4 Disorders of globin synthesis, 39

5 Conditions associated with white cell abnormalities, 51

6 Structure and function of lymphoid tissue, 59

7 Lymphomas: General principles, 65

8 Classifi cation of lymphoma, 73

9 Neoplastic disorders of lymphoid cells, 76

10 Myeloma and other paraproteinaemias, 87

11 Neoplastic disorders of myeloid cells, 93

12 Bone marrow transplantation, 104

13 Aplastic anaemia and pure red cell aplasia, 110

14 Haemostasis, abnormal bleeding and anticoagulant therapy, 114

15 Blood groups and blood transfusion, 132

16 Further reading, 143

Index, 147

Chris S.R. Hatton is Consultant Haematologist, Department of Haematology, The John Radcliffe Hospital, Oxford

Nevin C. Hughes–Jones is a Former Member of the Scientific Staff, Medical Research Council s Molecular Immunopathology Unit, and of the Department of Pathology, University of Cambridge

Deborah Hay is Wellcome Trust Clinical Training Fellow, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford

David Keeling is Consultant Haematologist, Oxford Haemophilia and Thrombosis Centre, Oxford