Hemostasis and Thrombosis: Practical Guidelines in Clinical Management

Hemostasis and Thrombosis: Practical Guidelines in Clinical Management Edited by Hussain I Saba MD, PhD Professor of Medicine Director of Hematology/Hemophilia/Hemostasis & Thrombosis Center USF College of Medicine Professor Emeritus Department of Malignant Hematology Moffitt Cancer Center and Research Institute Tampa, FL, USA   Harold R Roberts MD Emeritus Professor of Medicine and Pathology Division of Hematology / Oncology University of North Carolina Chapel Hill, NC, USA Hemostasis and thrombosis is a hugely important, changing and complex area that impacts many other medical specialties, affecting at least 10 million people in the United States alone. It is vital for physicians to recognize abnormalities of hemostasis and thrombosis and to be able to address these problems in their patients. Hemostasis and Thrombosis: Practical Guidelines in Clinical Management covers all aspects of the practical management of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment, and day–to–day management. The most clinically relevant material from the literature has been carefully compiled, along with:  – Discussions of new and upcoming diagnostic and therapeutic modalities – Practical clinical advice for all those dealing with coagulation, hemostasis and thrombosis Written by world leading specialists contributing their expertise in succinct text and focusing on the latest clinical guidance, Hemostasis and Thrombosis: Practical Guidelines in Clinical Management will benefit hematologists in training and in practice working in the fields of coagulation, hemostasis and thrombosis. Titles of related interest Practical Hemostasis and Thrombosis, 2nd Edition Key , ISBN 9781405184601 Hemophilia and Hemostasis: A Case–Based Approach to Management, 2nd Edition Ma, ISBN 9780470659762 Quality in Laboratory Hemostasis and Thrombosis, 2nd Edition Kitchen , ISBN 9780470671191   www.wiley.com/go/hematology

List of Contributors, xxx Preface, xxx 1 Theories of Blood Coagulation:  Basic concepts and recent updates Dougald M. Monroe, Maureane Hoffman 2 Vascular Endothelium, Influence on Hemostasis: Past and Present Hussain I. Saba, Sabiha R. Saba 3 Coagulation testing: basic and advanced clinical laboratory tests for the diagnosis of common hemostatic and thrombotic disorders Nils Egberg and Margareta Blombäck 4 Hemophilia A (Factor VIII Deficiency):  Clinical Bleeding and Management Pier Mannuccio Mannucci and Massimo Franchini 5 Hemophilia B (Factor IX deficiency): clinical manifestations and management R. S. Kasthuri, H. R. Roberts, P. E. Monahan 6 Factor XI Deficiency (Hemophilia C) Charles E. Bane, Anne T. Neff, and David Gailani 7 Factor VIII and IX Inhibitors in Hemophilia  Meera Chitlur and Jeanne Lusher 8 Treatment Options for Acquired Hemophilia Anjali Sharathkumar and David Green 9 Factor XII Deficiency (Hageman Factor Deficiency) Evi Stavrou and Alvin H. Schmaier 10 Inherited Combined Factor Deficiency States Asma Latif and Louis Aledort 11 Acute and Chronic ITP: Biology, Diagnosis and Management Samir Dalia and Benjamin Djulbegovic 12 Disseminated intravascular coagulation (DIC): diagnosis and management Stephanie J Davis, Craig M Kessler 13 Mechanisms of fibrinolysis and basic principles of management John W. Weisel and I. Litvinov 14 Post thrombotic Syndrome Jean–Philippe Galanaud, Susan R. Kahn 15 Von Willebrand Disease:  Clinical Aspects and Practical Management Francesco Rodeghiero, Alberto Tosetto, Giancarlo Castaman 16 Platelets in hemostasis: inherited and acquired qualitative disorders Noman Ashraf  and Hussain I. Saba  17 Contributions of Platelet Polyphosphate to Hemostasis and Thrombosis James H. Morrissey 18 Thrombotic Microangiopathy:  Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome: Biology, Diagnosis and Management Samir Dalia 19 Hemostasis and Aging Lodovico Balducci 20 Hemostatic problems in chronic and acute liver disease Ton Lisman and Robert J. Porte 21 Cancer and Thrombosis Erica Peterson and Agnes Lee 22 An Update on Low–Molecular–Weight Heparins Jawed Fareed, Debra Hoppensteadt, Walter P. Jeske Index