Transplantation at a Glance

The first basic overview of all aspects of transplantation with a clarity not to be found in more inaccessible textbooks.   This brand new title provides a succinct overview of both the scientific and clinical principles of organ transplantation and the types of organ transplant, featuring highly–illustrated information covering core topics in transplantation including: Organ donors Organ preservation Assessment of transplant recipients Indications for transplantation Immunology of transplantation Immunosuppression and its complications Overviews of thoracic and abdominal organ transplantation, including the kidneys, liver, heart and lungs Transplantation at a Glance is the ideal introduction for medical students, junior doctors, surgical trainees, immunology students, pharmacists, and nurses on transplant wards.

Preface 7 List of abbreviations 8 1 History of transplantation 10 Organ donors 2 Diagnosis of death and its physiology 12 3 Deceased organ donation 14 4 Live donor kidney transplantation 16 5 Live donor liver transplantation 18 Organ preservation 6 Organ preservation 20 Immunology of organ transplantation 7 Innate immunity 22 8 Adaptive immunity and antigen presentation 24 9 Humoral and cellular immunity 26 Histocompatibility in transplantation 10 Tissue typing and HLA matching 28 11 Detecting HLA antibodies 30 12 Antibody–incompatible transplantation 32 Organ allocation 13 Organ allocation 34 Immunosuppression 14 Immunosuppression: induction vs maintenance 36 15 Biological agents 37 16 T cell–targeted immunosuppression 38 Complications of immunosuppression 17 Side effects of immunosuppressive agents 40 18 Post–transplant infection 42 19 CMV infection 44 20 Post–transplant malignancy 46 Kidney transplantation 21 End–stage renal failure 48 22 Complications of ESRF 50 23 Dialysis and its complications 52 24 Assessment for kidney transplantion 54 25 Kidney transplantation: the operation 56 26 Surgical complications of kidney transplantation 58 27 Delayed graft function 60 28 Transplant rejection 62 29 Chronic renal allograft dysfunction 64 Pancreas and islet transplantation 30 Transplantation for diabetes mellitus 66 31 Pancreas transplantation 68 32 Islet transplantation 70 Liver transplantation 33 Causes of liver failure 72 34 Assessment for liver transplantation 74 35 Liver transplantation: the operation 76 36 Complications of liver transplantation 78 Intestinal transplantation 37 Intestinal failure and assessment 80 38 Intestinal transplantation 82 Heart transplantation 39 Assessment for heart transplantation 84 40 Heart transplantation: the operation 86 41 Complications of heart transplantation 88 Lung transplantation 42 Assessment for lung transplantation 90 43 Lung transplantation: the operation 92 44 Complications of lung transplantation 94 Composite tissue transplantation 45 Composite tissue transplantation 96 Xenotransplantation 46 Xenotransplantation 98 Index 100

Menna Clatworthy is at the University of Cambridge and Addenbrooke′s Hospital Christopher Watson is at the School of Clinical Medicine, University of Cambridge Michael Allison is at Cambridge University Hospitals NHS Foundation Trust John Dark is Professor of Cardiothoracic Surgery at the Regional Cardiothoracic Centre, The Freeman Hospital, Newcastle upon Tyne

“This is one of the best reviews of transplantation I have had the pleasure of reading. With its thorough collection of topics and its illustrations, it is a definite must read for those who are starting their training or spending a limited amount of time on a transplant service.”  ( Doody’s , 19 April 2013) This is a superbly produced small book with marvellous illustrations, and I am literally amazed how much information is presented in approximately 100 pages. The illustrations have been very carefully done and enhance the explanations in the text extremely well. The chapters range from a history of transplantation through organ donation and preservation; the immunology of organ transplantation; immunosuppression; complications of immunosuppression, and kidney, pancreas, liver, intestinal, and lung transplantations, finishing up with brief reviews of composite tissue transplantation and xenotransplantation. This is the ideal book to give to nurses or residents rotating through a transplantation unit or to scientists working in tissue typing or microbiology and virology with an interest in transplantation. Obviously, for those who stay in the field, they will need more in–depth information from the larger texts, but as a starter book, I have seen nothing better than this extremely good presentation. Each transplantation unit should have half a dozen or so available for those I have referred to above. ( Peter J. Morris , Transplantation journal, 2012)