Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action

This book overviews in vivo imaging techniques for both the development of drug delivery systems and controlled release dosages. Written by experts in their respective fields, the book discusses applications of quantitative imaging techniques in drug delivery. It helps readers understand the contemporary use of imaging in preclinical evaluation of drug delivery systems and to recognize challenges and potential pitfalls involved in utilizing imaging in developing new drug delivery systems. The chapters provide useful methods, practices, and guidance for pharmaceutical scientists encountering challenges in designing and evaluating drug delivery systems.

Preface Chapter 1: Introduction to Molecular Imaging Vikas Kundra Chapter 2: PET/SPECT: Instrumentation and Imaging Techniques Yuan–Chuan Tai Chapter 3: Photoacoustic Tomography and Its Application in Drug Delivery and Photothermal Therapy Liang Song Lihong Wang Chapter 4: Raman Microspectral Imaging for Label–Free Detection of Nanoparticle–Mediated Cellular and Sub–Cellular Drug Delivery Tatyana Chernenko, Lara Milane, Max Diem, and Mansoor Amiji Chapter 5: Quantitative Imaging in Drug Delivery Kooresh Shoghi Chapter 6: PET Imaging of Small–Molecular–Weight Drug Pharmacokinetics Stephen M. Moerlein and Zhude Tu Chapter 7: Imaging Peptides, Proteins, and Antibody Delivery F. L. Giesel and C. Kratochwil Chapter 8: In vivo imaging and delivery of siRNA Zdravka Medarova and Anna Moore Chapter 9: Imaging Cell Therapy Yijie Linag and Jeff W.M. Bulte Chapter 10: Radiolabeled Liposomes as Drug Delivery Nano–Theranostics William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins Chapter 11: Polymeric Micelles as Imaging Agents and Drug Delivery Systems Jun Zhao and Chun Li Chapter 12: Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic G.M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, S. A. Wickline Chapter 13: Cancer Theranostics with Hollow Gold Nanospheres Wei Lu and Chun Li Chapter 14: Imaging Pulmonary Drug Delivery Stephen Newman Chapter 15: In–vivo imaging for Validation of Oral Dose Performance Fiona McInnes and Howard Stevens Chapter 16: Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery Rajesh K. Uthamanthil and Mei Tian Chapter 17: Imaging Transcatheter delivery to Liver Tumors Adil AL–Nahhas, Meeran Naji, Imene Zerizer Chapter 18: Direct Visualization of Therapeutic Radionuclides Distribution Using Nuclear Medicine Imaging: I–131 in Metastatic Thyroid Carcinoma Ho Young Lee, June–Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, Myung Chul Lee Chapter 19: Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies Chi–Ming Lee, Katarina Varnäs, and Lars Farde