Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer

A groundbreaking new approach to understanding, preventing, and treating cancer

Supported by evidence from more than 1,000 scientific and clinical studies, this groundbreaking book demonstrates that cancer is a metabolic disease and, more importantly, that it can be more effectively managed and prevented when it is recognized as such. Moreover, the book provides detailed evidence that the traditional view of cancer as a genetic disease has been largely responsible for the failure to develop effective therapies and preventive strategies.

Cancer as a Metabolic Disease reevaluates the origins of cancer based on the latest research findings as well as several decades of studies exploring the defects in tumor cell energy metabolism. Author Thomas Seyfried is a biochemical geneticist who has been investigating the lipid biochemistry of cancer for thirty years. In this book, he carefully establishes why approaching cancer as a metabolic disease leads to better understanding and management of all aspects of the disease, including inflammation, vascularization, cell death, drug resistance, and genomic instability. In addition, the book explores:Origin of metastasisNew treatment strategies that target tumor cell energy metabolism, including the ketogenic dietMore effective prevention strategies in light of the metabolic origin of cancerCase studies and perspectives from the point of view of physicians, patients, and caregivers

Throughout the book, tables, figures, and graphs summarize key information and clarify complex concepts. In addition, the renown cancer biochemist Peter Pedersen from Johns Hopkins Medical School also provides a historical perspective on the importance of the information presented in his foreward to the book.

Cancer as a Metabolic Disease is essential reading for all cancer researchers and clinicians as well as public health professionals. By treating cancer as a metabolic disease, the book sets readers on a new, more promising path to understanding the origins of cancer and developing new, more effective strategies to treat and prevent it.

Chapter 1. Images of Cancer

Chapter 2. Confusion surrounds the origin of cancer

Chapter 3. Cancer Models

Chapter 4. Energetics of normal cells and cancer cells

Chapter 5. Respiratory Dysfunction in Cancer Cells

Chapter 6. The Warburg Dispute

Chapter 7. Is Respiration Normal in Most Cancer Cells?

Chapter 8. Is Mitochondrial Glutamine Fermentation the Missing Link in the Metabolic Theory of Cancer?

Chapter 9. Genes, Respiration, Viruses, Cancer

Chapter 10. Respiratory Injury, the retrograde response, and the origin of cancer

Chapter 11. Mitochondria: The ultimate tumor suppressor

Chapter 12. Linking Abnormalities in Growth Control, Telomerase Activity

Chapter 13. Metastasis

Chapter 14. Mitochrondrial Respiratory Dysfunction and the Extrachromosomal Origin of Cancer

Chapter 15. Nothing in Cancer Biology Makes Sense Except in the Light of Evolution

Chapter 16. Cancer Treatment Strategies

Chapter 17. Metabolic management of cancer

Chapter 18. Implementation of Metabolic Therapies for Cancer Management

Chapter 19. Cancer Prevention

Chapter 20. Case Studies and Personal Experiences in Using the Ketogenic Diet for Cancer Management

Chapter 21. Conclusions

THOMAS N. SEYFRIED, PhD, has taught and conducted research in the fields of neurogenetics, neurochemistry, and cancer for more than twenty-five years at Yale University and Boston College. He has published more than 150 scientific articles and book chapters and is on the editorial boards of Nutrition & Metabolism, Journal of Lipid Research, Neurochemical Research, and ASN Neuro.