The Chemical Biology of Nucleic Acids

Chemists have played a key role not only in establishing the chemical structure of DNA and RNA but also in helping to understand their structure–function relationship. As chemists have continued over the years to modify the structure and architecture of DNA and RNA for a better insight into their biological functions, Nature has provided new challenges by disclosing some unanticipated novel structures and pathways. These new insights into Nature pose questions where chemistry helps to obtain a deeper understanding.
The Chemical Biology of Nucleic Acids focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include:chemical synthesis of modified RNAexpansion of the genetic alphabet in nucleic acids by creating new base pairschemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotidesnucleic–acid–templated chemistrychemical biology of peptide nucleic acids (PNA)the interactions of small molecules with DNA and RNAthe architectural modules of folded RNAsgenesis and biological applications of locked nucleic acid (LNA)small non–coding RNA in bacteriamicroRNA–guided gene silencingnucleic acids based therapiesinnate immune recognition of nucleic acidlight–responsive nucleic acids for the spatiotemporal control of biological processesDNA methylationframeworks for programming RNA devicesRNA as a catalyst: The Diels–Alderase–Ribozymeevolving an understanding of RNA function by in vitro approachesthe chemical biology of aptamers: synthesis and applicationsnucleic acids as detection toolsbacterial riboswitch discovery and analysis
The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologist s, medicinal chemists, cell biologists, and molecular biologists.

Spis treści:
Foreword.
Preface.
List of Contributors.
1 Chemical Synthesis of Modified RNA (Claudia Hobartner and Falk Wachowius).
2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs (Ichiro Hirao and Michiko Kimoto).
3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides (Andreas Marx).
4 Nucleic Acid–templated Chemistry (Michael Oberhuber).
5 Chemical Biology of Peptide Nucleic Acids (PNAs) (Peter E. Nielsen).
6 The Interactions of Small Molecules with DNA and RNA (Yun Xie, Victor K. Tam and Yitzhak Tor).
7 The Architectural Motifs of Folded RNAs (Valerie Fritsch and Eric Westhof).
8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs) (Harleen Kaur and Souvik Maiti).
9 Small Non–coding RNA in Bacteria (Sabine Brantl).
10 MicroRNA–guided Gene Silencing (Gunter Meister).
11 Nucleic Acid–based Therapies (Britta Hoehn and John J. Rossi).
12 Innate Immune Recognition of Nucleic Acids (Stefan Bauer).
13 Light–responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes (Alexander Heckel and Gunter Mayer).
14 DNA Methylation (Albert Jeltsch and Renata Z. Jurkowska).
15 Frameworks for Programming RNA Devices (Maung Nyan Win, Joe C. Liang and Christina D. Smolke).
16 RNA as a Catalyst: The Diels–Alderase Ribozyme (Andres Jaschke).
17 Evolving an Understanding of RNA Function by In Vitro Approaches (Qing Wang and Peter J. Unrau).
18 The Chemical Biology of Aptamers: Synthesis and Applications (Gunter Mayer and Bernhard Wulffen).
19 Nucleic Acids as Detection Tools (Jeffrey C.F. Lam, Sergio Aguirre and Yingfu Li).
20 Bacterial Riboswitch Dis covery and Analysis (Tyler D. Ames and Ronald R. Breaker).
Index.

Okładka tylna:
Chemists have played a key role not only in establishing the chemical structure of DNA and RNA but also in helping to understand their structure–function relationship. As chemists have continued over the years to modify the structure and architecture of DNA and RNA for a better insight into their biological functions, Nature has provided new challenges by disclosing some unanticipated novel structures and pathways. These new insights into Nature pose questions where chemistry helps to obtain a deeper understanding.
The Chemical Biology of Nucleic Acids focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include:chemical synthesis of modified RNAexpansion of the genetic alphabet in nucleic acids by creating new base pairschemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotidesnucleic–acid–templated chemistrychemical biology of peptide nucleic acids (PNA)the interactions of small molecules with DNA and RNAthe architectural modules of folded RNAsgenesis and biological applications of locked nucleic acid (LNA)small non–coding RNA in bacteriamicroRNA–guided gene silencingnucleic acids based therapiesinnate immune recognition of nucleic acidlight–responsive nucleic acids for the spatiotemporal control of biological processesDNA methylationframeworks for programming RNA devicesRNA as a catalyst: The Diels–Alderase–Ribozymeevolving an understanding of RNA function by in vitro approachesthe chemical biology of aptamers: synthesis and applicationsnucleic acids as detection toolsbacterial riboswitch discovery and analysis
The Chemical Biology of Nucleic Acids is an essential compendiu m of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.