ADMET for Medicinal Chemists: A Practical Guide

Early ADMET explained: an integrated approach to successful drug development
This practical guide provides medicinal chemists insights into the field of early ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicology), giving them a how–to for implementing early ADMET testing in their workflows, and maximizing the success of drug candidates in preclinical and clinical studies.
The emphasis and themes illustrate the required collaboration and communication between team members from different specialties, such as chemists, biologists, formulators, toxicologists, and preclinical and clinical development specialists. The book demonstrates how this collaborative approach addresses long–standing productivity issues in the pharmaceutical industry, accelerates positive results, and helps improve the commercialization rate for therapeutic agents.
Written by a group of experts from diverse disciplines, ADMET for Medicinal Chemists covers all key areas of the drug development process, including:
Technical considerations when selecting preclinical drug candidates
Guidelines for how to avoid pitfalls during drug design and discovery
Proven cutting–edge approaches to preclinical studies and drug design
Essential computer methods for designing molecules with desired properties
Absorption and physicochemical properties of New Chemical Entities (NCE)
The concepts underlying pharmacokinetics
Assays for testing cardiac safety, genetic toxicity, and hepatic toxicity
In vivo toxicological considerations and complying with FDA requirements

Spis treści:
Preface.
Chapter 1: Introduction (Corinne Kay).
Chapter 2: In silico ADME/Tox Predictions (David Lagorce, Christelle Reynes, Anne–Claude Camproux, Maria A. Miteva, Olivier Sperandio, and Bruno O. Villoutreix).
Chapter 3: Absorption and Physicoc hemical Properties of the NCE (Jon Selbo and Po–Chang Chiang).
Chapter 4: ADME (Martin E. Dowty, Dean M. Messing, Yurong Lai, and Leonid (Leo) Kirkovsky).
Chapter 5: Pharmacokinetics for Medicinal Chemists (Leo Kirkovsky and Anup Zutshi).
Chapter 6: Cardiac Toxicity (Ralf Kettenhofen and Silke Schwengberg).
Chapter 7: Genetic Toxicity: In Vitro Approaches for Medicinal Chemists (Richard M. Walmsley and David Elder).
Chapter 8: Hepatic Toxicity (Jinghai James Xu and Keith Hoffmaster).
Chapter 9: In Vivo Toxicological Considerations (John P. Devine, Jr.).
Chapter 10: Pre–clinical Candidate Nomination and Development (Nils Bergenhem).
Chapter 11: Fragment–Based Drug Design: Considerations for Good ADME Properties (Haitao Ji).

Nota biograficzna:

KATYA TSAIOUN, PhD, is Chief Scientific Officer of Cyprotex and, previously, president and founder Apredica, which was acquired by Cyprotex. Both companies specialize in the rapid preclinical in vitro assessment of the ADME–Tox (Absorption, Distribution, Metabolism, Elimination, and Toxicity) properties of small–molecule and peptide therapeutics.
STEVEN A. KATES, PhD is Vice President of Research and Development at Ischemix. He is a highly experienced chemist with over twenty years in R&D for both life science products and human therapeutics, and has advanced several compounds through drug development from early preclinical to early clinical development. He has more than 100 patents and publications, including one book.

Okładka tylna:

Early ADMET explained: an integrated approach to successful drug development
This practical guide provides medicinal chemists insights into the field of early ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicology), giving them a how–to for implementing early ADMET testing in their workflows, and maximizing the success of drug candidates in preclinical and clinical studies.
The emphasis and themes illustrate the required collaboration and communication between team members from different specialties, such as chemists, biologists, formulators, toxicologists, and preclinical and clinical development specialists. The book demonstrates how this collaborative approach addresses long–standing productivity issues in the pharmaceutical industry, accelerates positive results, and helps improve the commercialization rate for therapeutic agents.
Written by a group of experts from diverse disciplines, ADMET for Medicinal Chemists covers all key areas of the drug development process, including:
Technical considerations when selecting preclinical drug candidates
Guidelines for how to avoid pitfalls during drug design and discovery
Proven cutting–edge approaches to preclinical studies and drug design
Essential computer methods for designing molecules with desired properties
Absorption and physicochemical properties of New Chemical Entities (NCE)
The concepts underlying pharmacokinetics
Assays for testing cardiac safety, genetic toxicity, and hepatic toxicity
In vivo toxicological considerations and complying with FDA requirements