Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Risk assessment and toxicogenomics — a practical review
The past decade has seen growing interest in the use of toxicogenomics for hazard evaluation and chemical safety assessment. This book addresses the need in the field for a comprehensive, up–to–date review of this emerging technology, providing toxicologists and regulatory scientists with practical considerations to take advantage of toxicogenomics when conducting risk assessment of industrial chemicals, pharmaceuticals, agrochemicals, and consumer products.
Written by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the principles of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends. The emphasis throughout is on practical risk assessment, highlighting applications of toxicogenomics in the risk assessment process across diverse and important areas.
Topics include:
Applications in mutagenicity, carcinogenicity, endocrine toxicity, organ–specific toxicity, population monitoring, and ecotoxicology
The use of toxicogenomics for enhancing mode–of–action and weight–of–evidence approaches
The role of toxicogenomics in dose–response analysis, cross–species extrapolations, and animal alternatives
The regulatory aspects of toxicogenomics, including chemical classification and prioritization for toxicity testing
Strategic approaches for the integration of toxicogenomics in safetyevaluation studies

Spis treści:
PREFACE.
CONTRIBUTORS.
1 TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER (Darrell R. Boverhof and B. Bhaskar Gollapudi).
2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT (Irene Baskerville–Abraham, Alison Willis, Bernard Gadagbui, and L ynne T. Haber).
3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD (Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel).
4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA (Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi).
5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS (Jiri Aubrecht and Ebru Caba).
6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS (Mark R. Fielden).
7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY (Jorge M. Naciff and George P. Daston).
8 STUDYING ORGAN–SPECIFIC TOXICITY USING GENE–EXPRESSION PROFILING (M. Ann Mongan and Hisham K. Hamadeh).
9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS (Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith).
10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT (Daniel L. Villeneuve, Dalma Martinovi´c, and Gerald T. Ankley).
11 ANALYSIS OF TRANSCRIPTOMIC DOSE–RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT (Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen).
12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES (Alan Dombkowski and J. Craig Rowlands).
13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES (Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans).
14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK (Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson).
15 STANDARDIZATION OF GENE–EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: AC TIVITIES IN JAPAN (Ken–ichi Aisaki and Jun Kanno).
16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION (Lois D. Lehman–McKeeman and William R. Foster).
17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH (Sarah N. Campion and Kim Boekelheide).
INDEX.

Nota biograficzna:

DARRELL R. BOVERHOF, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer–reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences.
B. BHASKAR GOLLAPUDI, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Company′s Global Toxicology & Environmental Research Laboratory. Dr. Gollapudi has authored or co–authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan.

Okładka tylna:

Risk assessment and toxicogenomics — a practical review
The past decade has seen growing interest in the use of toxicogenomics for hazard evaluation and chemical safety assessment. This book addresses the need in the field for a comprehensive, up–to–date review of this emerging technology, providing toxicologists and regulatory scientists with practical considerations to take advantage of toxicogenomics when conducting risk assessment of industrial chemicals, pharmaceuticals, agrochemicals, and consumer products.
Written by leading scientists experienced in the application of toxicogenomics data, this book includes a complete introduction to toxicogenomics and the princi ples of risk assessment, examines the potential of the technology to improve risk assessment practices, and offers insight into promising future trends. The emphasis throughout is on practical risk assessment, highlighting applications of toxicogenomics in the risk assessment process across diverse and important areas.
Topics include:
Applications in mutagenicity, carcinogenicity, endocrine toxicity, organ–specific toxicity, population monitoring, and ecotoxicology
The use of toxicogenomics for enhancing mode–of–action and weight–of–evidence approaches
The role of toxicogenomics in dose–response analysis, cross–species extrapolations, and animal alternatives
The regulatory aspects of toxicogenomics, including chemical classification and prioritization for toxicity testing
Strategic approaches for the integration of toxicogenomics in safetyevaluation studies