Cardiovascular Effects of Inhaled Ultrafine and Nano–Sized Particles

A comprehensive overview of the cardiovascular effects of air pollution
Scientists have known for decades that air pollution causes serious health effects. Only recently has a definitive set of epidemiological and toxicological data become available demonstrating that exposure to particulate air pollution contributes to atherosclerosis and can trigger myocardial ischemia or arrhythmias.
Cardiovascular Effects of Inhaled Ultrafine and Nano–Sized Particles provides a timely and detailed account of the complex issues that determine the impact of air pollution on the cardiovascular system. With contributions from world leaders in the field, it provides an up–to–date review of the key mechanisms involved in the induction and progression of these cardiovascular conditions.
Integrating knowledge across such disciplines as epidemiology, toxicology, atmospheric sciences, clinical sciences, and risk assessment, the book:
Includes case studies, and both toxicological and epidemiological data
Reviews the implications for health policy and regulations
Covers sources and characterization, methods of exposure, and the impact of particulate matter on cells and systems
Describes the role of particles in the pathophysiology of cardiovascular disease, and potential environmental and therapeutic interventions
This book is a core text for scientists, clinicians, and public health regulators wanting to understand more thoroughly the causality and mechanisms of disease. From procedures to policy, the text is comprehensive and essential for students and professionals alike.

Spis treści:
About the editors.
Preface.
Forword (Paul Borm).
List of authors.
Section I. Issue framing.
1. Overview.
2. Acute effects of particulate matter on cardiovascular events.
3. Chronic effects of particulate matter on cardiovascular disease.
Section II. Expo sure.
4. Particle characterization.
5. Exposure assessment ambient ultrafine particles.
6. From exposure to dose.
7. Translocation of Inhaled Nanoparticles.
8. Role of chemical composition in determining the cardiovascular effects of particles.
Section III. Methodology.
9. In vitro studies.
10. Experimental studies in animals.
11. Human exposure studies.
12. Panel studies.
Section IV. Particles and cardiovascular disease –mechanisms.
A. ATHEROGENESIS.
13. Particulates and oxidative stress.
14. Role of inflammation in the atherogenic effects of particulate matter.
15. Inhaled particles, postprandial lipids and their possible contribution to atherogenesis.
16. Inhaled particulate matter and atherosclerosis in humans.
B. VASCULAR DYSFUNCTION .
17. Effects of particulates on the pulmonary vasculature.
18. Particulate Matter, Hypertension, and the Metabolic Syndrome.
19. Particles and the vascular endothelium.
C. THROMBOSIS.
20. Particles, coagulation and thrombosis.
21. Particles and the pathogenesis of atherothrombosis.
D. ARRHYTHMIA (NLM to edit).
22. Particles and the autonomic nervous system.
23. Air pollution and cardiac arrhythmia.
Section V. Environmental and public health policy.
24. Risk assessment.
25. Environmental regulation of particulate matter.
26. From ambient ultrafine particles to nanotechnology and nanotoxicology.

Nota biograficzna:

Flemming R. Cassee is head of the Department of Inhalation Toxicology, deputy head of the Center for Environmental Health, and leader of the program on air pollution and health at the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Nicholas L. Mills is a British Heart Foundation Clinical Fellow at the University of Edinburgh and Specialist Registrar in Cardiology at the Royal Infirmary of Edinburgh.
David E. Newby is the British Heart Foundation John Wheatley Chair of Cardiology at the University of Edinburgh. He is a Consultant Interventional Cardiologist at the Royal Infirmary of Edinburgh, Director of the Wellcome Trust Clinical Research Facility, Director of the Clinical Research Imaging Centre, and Director of Research and Development for NHS Lothian.

Okładka tylna:

A comprehensive overview of the cardiovascular effects of air pollution
Scientists have known for decades that air pollution causes serious health effects. Only recently has a definitive set of epidemiological and toxicological data become available demonstrating that exposure to particulate air pollution contributes to atherosclerosis and can trigger myocardial ischemia or arrhythmias.
Cardiovascular Effects of Inhaled Ultrafine and Nano–Sized Particles provides a timely and detailed account of the complex issues that determine the impact of air pollution on the cardiovascular system. With contributions from world leaders in the field, it provides an up–to–date review of the key mechanisms involved in the induction and progression of these cardiovascular conditions.
Integrating knowledge across such disciplines as epidemiology, toxicology, atmospheric sciences, clinical sciences, and risk assessment, the book:
Includes case studies, and both toxicological and epidemiological data
Reviews the implications for health policy and regulations
Covers sources and characterization, methods of exposure, and the impact of particulate matter on cells and systems
Describes the role of particles in the pathophysiology of cardiovascular disease, and potential environmental and therapeutic interventions
This book is a core text for scientists, clinicians, and public health regulators wanting to understand more thoroughly the causality and mechanisms of disease. From procedures to policy, the text is comprehensive and essential for students and professionals alike.