Six–Membered Transition States in Organic Synthesis

How stereoselective reactions occur through six–membered transition states
This book is a definitive guide for furthering readers′ understanding of the amazing features of six–membered transition states in stereoselective organic reactions. Comprehensive and logically organized, it:
Covers reactions classified in four categories: [3,3]–sigmatropic rearrangements, aldol reactions, metal allylation reactions, and stereoselective reductions
Includes "General Considerations" for each category in which the author presents computational studies that support a proposal of a six–membered state
Provides a thorough discussion of each reaction category, including an introduction and history, a discussion of the corresponding six–membered transition state, and details of synthetic applications in natural product synthesis
Incorporates real–life applications of these transition states to the total syntheses of biologically active natural products
Covers literature up to 2006, with the original references cited for further study
This is a premier reference for organic chemists, medicinal chemists, and physical organic chemists and researchers in industries and institutes focusing on fine chemicals, including pharmaceuticals, agriculture/biotech, and polymers/materials. It is also an illuminating text for upper–level undergraduate and graduate students in organic chemistry. The author′s primary goal is to assist professors, researchers, and students in proposing reasonable transition states for the description of newly discovered stereo–selective reactions.

Spis treści:
Preface.
Introduction.
1 [3,3]–Sigmatropic Rearrangements.
General Considerations.
Reactions.
1.1 Claisen Rearrangement.
1.2 Johnson–Claisen Rearrangement.
1.3 Ireland–Claisen Rearrangement.
1.4 Cope Rearrangement.
1.5 Anionic Oxy–Cope Rearrangement.
1.6 Aza–Cope–Mannich Reaction.
2 Aldol Reactions.
General Considerations.
Reactions.
2.1 Asymmetric Syn–Aldol Reaction.
2.2 Asymmetric Anti–Aldol Reaction.
2.3 Proline–Catalyzed Asymmetric Aldol Reaction.
3 Metal Allylation Reactions.
General Considerations.
Reactions.
3.1 Boron Allylation Reaction.
3.2 Silicon Allylation Reaction.
4 Stereoselective Reductions.
General Considerations.
Reactions.
4.1 Diastereoselective Syn–Reduction of β–Hydroxy Ketones.
4.2 Diastereoselective Anti–Reduction of β–Hydroxy Ketones.
4.3 Asymmetric Reduction.
List of Copyrighted Materials.
Abbreviations.
Subject Index.
Scheme Index of Natural Products.

Nota biograficzna:
Jaemoon Yang, PhD, is a lecturer in organic chemistry at Montana State University in Bozeman, Montana. Dr. Yang was born in South Korea; he earned his PhD under Dr. Craig Wilcox at the University of Pittsburgh in 2000. Following a postdoctoral fellowship with Dr. Huw Davies at SUNY Buffalo, Dr. Yang started teaching organic chemistry and conducting research on asymmetric hydroamination via chiral lanthanide complexes at Montana State University with Dr. Tom Livinghouse.

Okładka tylna:
How stereoselective reactions occur through six–membered transition states
This book is a definitive guide for furthering readers′ understanding of the amazing features of six–membered transition states in stereoselective organic reactions. Comprehensive and logically organized, it:
Covers reactions classified in four categories: [3,3]–sigmatropic rearrangements, aldol reactions, metal allylation reactions, and stereoselective reductions
Includes "General Considerations" for each category in which the author presents computational studies that support a proposal of a six–membered state
Provides a thorough discussion of each reaction category, including an introduction and history, a discussion of the corresponding six–membered transition state, and details of synthetic applications in natural product synthesis
Incorporates real–life applications of these transition states to the total syntheses of biologically active natural products
Covers literature up to 2006, with the original references cited for further study
This is a premier reference for organic chemists, medicinal chemists, and physical organic chemists and researchers in industries and institutes focusing on fine chemicals, including pharmaceuticals, agriculture/biotech, and polymers/materials. It is also an illuminating text for upper–level undergraduate and graduate students in organic chemistry. The author′s primary goal is to assist professors, researchers, and students in proposing reasonable transition states for the description of newly discovered stereo–selective reactions.