RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems

Latest discoveries in RNA and DNA editing research, with expert forecasts of the field′s future directions
RNA and DNA Editing assembles a team of leading experts who present the latestdiscoveries in the field alongside the latest models and methodology. In addition,the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes.
This book is divided into four sections, providing a clear, contextual map of the field:
Diversification of the Proteome through RNA and DNA Editing discusses the occurrence of editing sites within transcriptomes and their distribution within individual RNAs in order to explore why nucleic acid sequences are edited instead of encoded genomically
Functional Coordination of RNA Editing with Other Cellular Mechanisms brings to the forefront why RNA and DNA editing is essential for cell survival and adaptation
Predictive Studies underscores the power of computational approaches in identifying novel editing sites and predicting the biological consequences of editing at these sites
Structural Approaches presents comparative structural analyses that suggest conserved protein folds and implicate, in some instances, their ancient phylogenic origins as components of editing machinery
This book not only discusses the current state of research in depth, it also gives new contributors an opportunity to express their vision. The perspectives voiced by these authors are provocative and intended to motivate discussion and inspire new experiments. Finally, this book will promote new hypotheses and models that can serve as springboards for the next generation of discoveries in the field.

Spis treści:
Preface.
Acknowledgements.
Contributors.
Part I: Diversification of the Proteome through RNA and DNA Editing.
Chapter 1. Diversifying Exon Code Through A–To–I RNA Editing.
Chapter 2. Antibody Gene Diversification by Aid–Catalyzed DNA Editing.
Chapter 3. Protein–Protein and RNA–Protein Interactions in U–Insertion/Deletion RNA Editing Complexes.
Chapter 4. Machinery of RNA editing in Plant Organelles.
Part II: Functional Coordination of RNA Editing With Other Cellular Mechanisms.
Chapter 5. Transfer RNA Editing Enzymes: At the Crossroads of Affinity and Specificity.
Chapter 6. A–To–I Editing as a Co–Transcriptional RNA Processing Event.
Chapter 7. Studying and Working with Ribonucleoproteins that Catalyze H/ACA Guided RNA Modification.
Chapter 8. Functional Roles of Spliceosomal SNRNA Modifications in Pre–mRNA Splicing.
Chapter 9. A Role for A–To–I Editing in Gene Silencing.
Chapter 10. biological Implications and Broader–Range Functions For Apobec–1 and Apobec–1 Complementation Factors (ACF)
Chapter 11. Antiviral Function of APOEC3 Cytidine Deaminases.
Part III: Predictive Structures.
Chapter 12. A–To–I Editing of ALU Repeats.
Chapter 13. RNA Editing in Dinoflagellates and Implications for the Evolutionary History of the Editing Machinery.
Part IV: Structural Approaches.
Chapter 14. The Box C/D RNPs: Evolutionarily Ancient Nucleotide Modification Complexes.
Chapter 15. Structural Features of the Adar Family of Enzymes and Their Substrates.
Chapter 16. Chemistry, Phylogeny, and three–Dimensional Structure of the Apobec Protein Family.
Index.

Nota biograficzna:

Harold C. Smith, PhD, is Professor in the Department of Biochemistry and Biophysics at the University of Rochester and the founder and Chief Scientific Officerof OyaGen, a biotech company that develops drugs that target editing enzymes. Dr. Smith organized the first Gordon Research Conference on RNA Editing in 1997 and holds four patents.

Okładka tylna:

Latest discoveries in RNA and DNA editing research, with expert forecasts of the field′s future directions
RNA and DNA Editing assembles a team of leading experts who present the latestdiscoveries in the field alongside the latest models and methodology. In addition,the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes.
This book is divided into four sections, providing a clear, contextual map of the field:
Diversification of the Proteome through RNA and DNA Editing discusses the occurrence of editing sites within transcriptomes and their distribution within individual RNAs in order to explore why nucleic acid sequences are edited instead of encoded genomically
Functional Coordination of RNA Editing with Other Cellular Mechanisms brings to the forefront why RNA and DNA editing is essential for cell survival and adaptation
Predictive Studies underscores the power of computational approaches in identifying novel editing sites and predicting the biological consequences of editing at these sites
Structural Approaches presents comparative structural analyses that suggest conserved protein folds and implicate, in some instances, their ancient phylogenic origins as components of editing machinery
This book not only discusses the current state of research in depth, it also gives new contributors an opportunity to express their vision. The perspectives voiced by these authors are provocative and intended to motivate discussion and inspire new experiments. Finally, this book will promote new hypotheses and models that can serve as springboards for the next generation of discoveries in the fie ld.