The Mizoroki–Heck Reaction

The Mizoroki–Heck reaction is a palladium–catalyzed carbon–carbon bond forming process which is widely used in organic and organometallic synthesis. It has seen increasing use in the past decade as chemists look for strategies enabling the controlled construction of complex carbon skeletons. The Mizoroki–Heck Reaction is the first dedicated volume on this important reaction, including topics on:mechanisms of the Mizoroki–Heck reactionintermolecular Mizoroki–Heck reactionsfocus on regioselectivity and product outcome in organic synthesiswaste–minimized Mizoroki–Heck reactionsintramolecular Mizoroki–Heck reactionsformation of heterocycleschelation–controlled Mizoroki–Heck reactionsthe Mizoroki–Heck reaction in domino processesoxidative heck–type reactions (Fujiwara–Moritani reactions)Mizoroki–Heck reactions with metals other than palladiumligand design for intermolecular asymmetric Mizoroki–Heck reactionsintramolecular enantioselective Mizoroki–Heck reactionsdesymmetrizing Mizoroki–Heck reactionsapplications in combinatorial and solid phase syntheses, and the development of modern solvent systems and reaction techniquesthe asymmetric intramolecular Mizoroki–Heck reaction in natural product total synthesis
Several chapters are devoted to asymmetric Heck reactions with particular focus on the construction of otherwise difficult–to–obtain sterically congested tertiary and quaternary carbons. Industrial and academic applications are highlighted in the final section. The Mizoroki–Heck Reaction will find a place on the bookshelves of any organic or organometallic chemist.

Spis treści:
Foreword by Professor Richard F. Heck
1 Mechanisms of the Mizoroki–Heck Reaction
Anny Jutand
2 Fo cus on Catalyst Development and Ligand Design
Irina P. Beletskaya and Andrei V. Cheprakov
3 Focus on Regioselectivity and Product Outcome in Organic Synthesis
Peter Nilsson, Kristofer Olofsson and Mats Larhed
4 Waste–Minimized Mizoroki–Heck Reactions
Lukas Gooßen and Käthe Gooßen
5 Formation of Carbocycles
Axel B. Machotta and Martin Oestreich
6 Formation of Heterocycles
Thierry Muller and Stefan Bräse
7 Chelation–Controlled Mizoroki–Heck Reactions
Kenichiro Itami and Jun–ichi Yoshida
8 The Mizoroki–Heck Reaction in Domino Processes
Lutz F. Tietze and Laura M. Levy
9 Oxidative Heck–Type Reactions (Fujiwara–Moritani Reactions)
Eric M. Ferreira, Haiming Zhang and Brian M. Stoltz
10 Mizoroki–Heck Reactions with Metals Other than Palladium
Lutz Ackermann and Robert Born
11 Ligand Design for Intermolecular Asymmetric Mizoroki–Heck Reactions
Anthony G. Coyne, Martin O. Fitzpatrick and Patrick J. Guiry
12 Intramolecular Enantioselective Mizoroki–Heck Reactions
James T. Link and Carol K. Wada
13 Desymmetrizing Heck Reactions
Masakatsu Shibasaki and Takashi Ohshima
14 Combinatorial and Solid–Phase Syntheses
Thierry Muller and Stefan Bräse
15 Mizoroki–Heck Reactions: Modern Solvent Systems and Reaction Techniques
Werner Bonrath, Ulla L´etinois, Thomas Netscher and Jan Schütz
16 The Asymmetric Intramolecular Mizoroki–Heck Reaction in Natural Product Total Synthesis
Amy B. Dounay and Larry E. Overman