A Handbook of Mouse Models of Cardiovascular Disease

The availability of well–defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools.  Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook will enable scientists to develop these models in their own laboratories.  It contains detailed advice on the issues that investigators need to consider before starting their experiments.  It then provides essential information about experimental procedures, specific instruments and technical knowledge and will prove an indispensable guide to all scientists planning to work with these mouse models.
This book includes a brief introduction to each disease, followed by a detailed description of the methods and materials used to establish the relevant mouse model.  Each chapter has been written by an expert familiar with that system, who provides helpful discussion of the problems that may be encountered and  examples of applications of the model. Importantly, each technique is clearly illustrated on the accompanying CD, so that researchers can observe the operational procedures directly.
With coverage of all the major mouse models of cardiovascular disease, this book may be used to obtain a broad overview of commonly used methods and, more importantly, as a comprehensive source of detailed information on the development and study of such models.  It will prove essential reading to all those working on experimental animal models of cardiovascular disease, from students to independent investigators.


Spis treści:
Contributors.
Preface.
1 general information (Hermann Dietrich).
2 Naturally occurring variation among mous e strains (Weibin Shi and Aldons J. Lusis).
3 Transgenic and Gene–targeted Mice of Hyperlipidemia (Yadong Huang).
4 Bone Marrow Transplantation: the methodology and its application in atherosclerosis research Menno (P.J. de Winter and Marten H. Hofker Introduction).
5 Hyperlipidemia–induced Atherosclerosis (Alan Daugherty and Debra L. Rateri).
6 Magnetic Resonance Imaging Evaluation of Atherosclerotic Plaque (Martina A McAteer, Jurgen E. Schneider and Robin P. Choudhury).
7 Plaque Rupture (Christopher Jackson).
8 Perivascular Cuff–, Electronic– and Chemical Injury–induced Stenosis Nuno (M.M. Pires, Margreet R. de Vries, Abbey Schepers, Daniel Eefting, Jan–Willem H.P. Lardenoye and Paul H.A. Quax).
9 Flow–induced Vascular Remodeling (Vycheslav A. Korshunov and Bradford C. Berk).
10 Vein Graft Atherosclerosis (Yanhua Hu and Qingbo Xu).
11 Angiotensin II–induced aortic aneurysms (Yi–Xin Wang, Lisa A. Cassis and Alan Daugherty).
12 Carotidojugular Fistula (Yves Castier, Alain Tedgui and Stéphanie Lehoux).
13 Applications to the Study of Stroke (Jaques Seylaz and Elisabeth Pinard).
14 Identifying Congenital Heart Defects in Embryos Using High–resolution Magnetic Resonance Imaging (Jürgen E. Schneider and Shoumo Bhattacharya).
15 Allograft Arteriopathy: Heterotopic Heart Transplantation and Aortic Interposition Grafts (Koichi Shimizu and Richard N. Mitchell).
16 Heart Preconditioning Analysis (Guang–Wu Wang, David A. Liem, Steven Le and Peipei Ping).
17 Myocardial Ischemia–Reperfusion (Bernhard Metzler, Elisabetta Conci and Omar Pachinger).
18 Cardiac Hypertrophy (David J. Grieve, Alison C. Cave and Ajay M. Shah).
19 The Retrogradely Perfused Isolated Heart Model (Mihaela M. Mocanu and Derek M. Yellon).
20 Measurement of Pulse Wave Velocity (Yi–Xin Wang).
21 Gene Transfer to Dyslipidemic Mice (Kazuhiro Oka, Andrew H. Baker and Lawrence Chan).
22 Hypertension (Daiana Weiss and W. Robert Taylor).
23 Ischemia–induced Neovascularisation (Ken–ichiro Sasaki, Christopher Heeschen, Alexandra Aicher and Stefanie Dimmeler).
24 Angiogenesis in Biomatrices and Artificial Materials (Pieter Koolwijk and Victor W.M. van Hinsburgh).
25 Venous Thrombosis (Alberto Smith, James Gossage and Bijan Moderai).
26 Virus–induced Vasculitis (Phillippe Krebs and Burkhard Ludewig).
27 Surgically induced Chronic Heart Failure (Craig A. Lygate and Stefan Neubauer).
28 Atrial Fibrillation (Sander Verheule, Toshiako Sato and Jeffrey E. Olgin).

Nota biograficzna:
Qingbo Xu. John Parker Professor of Vascular Biology, Department of Cardiac and Vascular Sciences, St George′s Hospital Medical School.
Professor Xu has an excellent standing in the field of atherosclerosis with an outstanding scientific track record. He is part of a European Network of Excellence on vascular biology, which is a large consortium of experts. He is an expert in mouse models and in microsurgery. His group pioneers the study of heat shock proteins in atherogenesis and has established the first mouse model of vein graft atherosclerosis, which is proven to be powerful in studying the mechanisms of progenitor cells participating in atherosclerosis. Professor Xu’s group also generated the first PKC knockout mice and analysed protein profiles of cardiovascular cells in these mice.

Okładka tylna:
The availability of well–defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools.  Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook will enable scientists to develop these models in their own laboratories.  It contains detailed advice on the issues that investigators need to consider before starting their experiments.  It then provides essential information about experimental procedures, specific instruments and technical knowledge and will prove an indispensable guide to all scientists planning to work with these mouse models.
This book includes a brief introduction to each disease, followed by a detailed description of the methods and materials used to establish the relevant mouse model.  Each chapter has been written by an expert familiar with that system, who provides helpful discussion of the problems that may be encountered and  examples of applications of the model. Importantly, each technique is clearly illustrated on the accompanying CD, so that researchers can observe the operational procedures directly.
With coverage of all the major mouse models of cardiovascular disease, this book may be used to obtain a broad overview of commonly used methods and, more importantly, as a comprehensive source of detailed information on the development and study of such models.  It will prove essential reading to all those working on experimental animal models of cardiovascular disease, from students to independent investigators.