Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments

Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

Presents content by renowned authors who review the state-of-the-art in preclinical research and provide their views and perspectives for the future of the fieldProvides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics coveredIncludes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

1. Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Down syndrome Eugene Yu 2. The trisomy paradox: gene expression dysregulation domains Stylianos Antonarakis 3. Influence of allelic differences in mouse models of Down syndrome Randall J. Roper 4. Modelling Down syndrome in cells: from stem cells to organoids Dean Nizetic 5. Modelling Down syndrome in animals from the early stage to the new generation of models Yann Herault 6. Mapping behavioral landscapes in Down syndrome animal models María Martínez de Lagrán 7. Using mouse models to understand Alzheimer’s disease mechanisms in the context of trisomy of Chromosome 21 Frances Kendra Wiseman 8. Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome Carmen Martínez Cué 9. Focusing on cellular biomarkers: the endolysosomal pathway in Down syndrome Marie Claude Potier 10. Forecasting the future roadmap for Down syndrome preclinical research William Mobley