Thermoregulation Part II: From Basic Neuroscience to Clinical Neurology

Thermoregulation, Part II: From Basic Neuroscience to Clinical Neurology, Volume 155 not only reviews how body temperature regulation changes in neurological diseases, but also how this aspect affects the course and outcomes of each disease. Other sections of the volume review three therapeutic approaches that are aimed at manipulating body temperature, including induced hypothermia, induced hyperthermia and antipyretic therapy. The book is comprised of nine sections across two volumes, five dealing with the basic aspects of body temperature regulation and four dealing with the clinical aspects. Basic sections cover the Thermoregulation system, Thermoreceptors, Thermoeffectors, Neural pathways, and Thermoregulation as a homeostatic function.

In addition, the book covers the physiology and neuroanatomy of the thermoregulation system and provides descriptions of how the regulation of body temperature intervenes with other physiological functions (such as sleep, osmoregulation, and immunity), stress, exercise and aging. Basic sections serve as an introduction to the four clinical sections: Body Temperature, Clinical Significance, Abnormal Body Temperature, Thermoregulation in Neurological Disease and Therapeutic Interventions.

Presents a clear, logical pathway from the fundamental physiology of thermoregulation, through neurobiology, to clinical applications and diseaseEnables researchers and clinicians to better understand the value of temperature measurement in disease and the use of temperature as a therapy Integrates content from a broad field of research, including topics on the molecular physiology of temperature receptors, to the management of accidental hypothermia

SECTION VI. Normal and abnormal body core and peripheral temperatures 29. Body temperature and clinical thermometry 30. Brain Temperature: From Physiology and Pharmacology to Neuropathology 31. Heat exhaustion 32. Heatstroke 33. Accidental hypothermia 34. Fever and hypothermia in systemic inflammation 35. Stress-induced hyperthermia and hypothermia 36. Body temperature regulation and drugs of abuse 37. Body temperature regulation and anesthesia 38. Malignant hyperthermia 39. Neuroleptic malignant syndrome and serotonin syndrome 40. Acral coldness – severely reduced blood flow to fingers and toes 41. Consequences of Perioperative Hypothermia

SECTION VII. THERMOREGULATION IN NEUROLOGICAL DISEASE  42. Thermoregulatory Dysfunction in Multiple Sclerosis 43. Thermoregulation in Parkinson disease 44. Hypothermia as a risk factor for Alzheimer disease 45. Thermoregulation in epilepsy 46. Thermoregulation in amyotrophic lateral sclerosis 47. Thermoregulatory Disorders in Huntington's Disease 48. Thermoregulation in neuropathies 49. Thermoregulation in brain injury 50. Thermoregulation Following Spinal Cord Injury

SECTION VIII. THERAPEUTIC INTERVENTIONS 51. Hypothermia in Acute Ischemic Stroke Therapy 52. Selective brain hypothermia 53. Therapeutic hyperthermia 54. Antipyretic therapy: Clinical pharmacology